The emerging role of 12/15-lipoxygenase in ischemic stroke
The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. Ischemic stroke is a devastating disea...
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| Language: | English |
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Elsevier
2025-02-01
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| Series: | Brain Research Bulletin |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0361923025000061 |
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| author | Xuening Wang Qiuji Shao Yuan Gao |
| author_facet | Xuening Wang Qiuji Shao Yuan Gao |
| author_sort | Xuening Wang |
| collection | DOAJ |
| description | The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. Ischemic stroke is a devastating disease in which the occlusion of cerebral arteries leads to a series of pathophysiological changes in brain tissue, triggering an inflammatory cascade within the brain that results in neuroinflammation. Prior research has shown that 12/15-LOX levels in the brain are elevated following stroke. In this review, we elaborate on the key pathological mechanisms that unfold following ischemic stroke, including neuroinflammation, oxidative stress, neuronal apoptosis, and blood-brain barrier disruption, and present evidence demonstrating that 12/15-LOX inhibition could be used to treat ischemic stroke through various avenues. Furthermore, we list currently available inhibitors of 12/15-LOX and the preclinical or clinical applications, offering novel insights for the early diagnosis, prognosis evaluation, and targeted therapy in neurological diseases. |
| format | Article |
| id | doaj-art-455db5d9a09e44cbb1ea93bbc5920911 |
| institution | Kabale University |
| issn | 1873-2747 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Brain Research Bulletin |
| spelling | doaj-art-455db5d9a09e44cbb1ea93bbc59209112025-02-07T04:46:40ZengElsevierBrain Research Bulletin1873-27472025-02-01221111194The emerging role of 12/15-lipoxygenase in ischemic strokeXuening Wang0Qiuji Shao1Yuan Gao2Department of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, China; Institute of Clinical Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, ChinaDepartment of Cerebrovascular Disease, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, ChinaDepartment of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, China; Institute of Clinical Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, China; Corresponding author at: Department of Pharmacology, School of Basic Medicine, Zhengzhou University, Zhengzhou, China.The arachidonic acid metabolic pathway is a classic inflammatory pathway. 12/15-lipoxygenase (LOX), a member of the lipoxygenase family that metabolizes arachidonic acid, has been implicated in the pathogenesis of numerous central nervous system (CNS) diseases. Ischemic stroke is a devastating disease in which the occlusion of cerebral arteries leads to a series of pathophysiological changes in brain tissue, triggering an inflammatory cascade within the brain that results in neuroinflammation. Prior research has shown that 12/15-LOX levels in the brain are elevated following stroke. In this review, we elaborate on the key pathological mechanisms that unfold following ischemic stroke, including neuroinflammation, oxidative stress, neuronal apoptosis, and blood-brain barrier disruption, and present evidence demonstrating that 12/15-LOX inhibition could be used to treat ischemic stroke through various avenues. Furthermore, we list currently available inhibitors of 12/15-LOX and the preclinical or clinical applications, offering novel insights for the early diagnosis, prognosis evaluation, and targeted therapy in neurological diseases.http://www.sciencedirect.com/science/article/pii/S036192302500006112/15-LOX12/15-LOX inhibitorsNeuroinflammationIschemic stroke |
| spellingShingle | Xuening Wang Qiuji Shao Yuan Gao The emerging role of 12/15-lipoxygenase in ischemic stroke Brain Research Bulletin 12/15-LOX 12/15-LOX inhibitors Neuroinflammation Ischemic stroke |
| title | The emerging role of 12/15-lipoxygenase in ischemic stroke |
| title_full | The emerging role of 12/15-lipoxygenase in ischemic stroke |
| title_fullStr | The emerging role of 12/15-lipoxygenase in ischemic stroke |
| title_full_unstemmed | The emerging role of 12/15-lipoxygenase in ischemic stroke |
| title_short | The emerging role of 12/15-lipoxygenase in ischemic stroke |
| title_sort | emerging role of 12 15 lipoxygenase in ischemic stroke |
| topic | 12/15-LOX 12/15-LOX inhibitors Neuroinflammation Ischemic stroke |
| url | http://www.sciencedirect.com/science/article/pii/S0361923025000061 |
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