Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood

The ketogenic diet (KD) is a dietary regimen characterized by low carbohydrate intake and moderate protein levels, designed to simulate a fasting state and induce ketosis for the production of ketone bodies from fat. Emerging research underscores KD’s potential in improving cognitive functions and r...

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Main Authors: Yuhan Jiang, Yili Chen, Youmeng Chen, Xinrong Gong, Zhiyu Chen, Xin Zhang
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Foods
Subjects:
Online Access:https://www.mdpi.com/2304-8158/14/7/1215
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author Yuhan Jiang
Yili Chen
Youmeng Chen
Xinrong Gong
Zhiyu Chen
Xin Zhang
author_facet Yuhan Jiang
Yili Chen
Youmeng Chen
Xinrong Gong
Zhiyu Chen
Xin Zhang
author_sort Yuhan Jiang
collection DOAJ
description The ketogenic diet (KD) is a dietary regimen characterized by low carbohydrate intake and moderate protein levels, designed to simulate a fasting state and induce ketosis for the production of ketone bodies from fat. Emerging research underscores KD’s potential in improving cognitive functions and regulating mood. Investigations into its safety and efficacy have centered on its anti-inflammatory properties and its impact on neurological health and the gut–brain axis (GBA). This review delves into the relationship between the KD and gut microbiota, emphasizing its potential role in cognitive enhancement and mood stabilization, particularly for managing mood disorders and depression. The investigation of the KD’s physiological effects and its role in promoting cognition and emotion through gut microbiota will pave the way for innovative approaches to personalized dietary interventions.
format Article
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institution OA Journals
issn 2304-8158
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publishDate 2025-03-01
publisher MDPI AG
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series Foods
spelling doaj-art-4558b3ad60fb4b54aa347947d4d4cabb2025-08-20T02:09:19ZengMDPI AGFoods2304-81582025-03-01147121510.3390/foods14071215Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and MoodYuhan Jiang0Yili Chen1Youmeng Chen2Xinrong Gong3Zhiyu Chen4Xin Zhang5Department of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaNingbo Institute for Drug Control, Ningbo 315048, ChinaDepartment of Food Science and Engineering, Ningbo University, Ningbo 315211, ChinaThe ketogenic diet (KD) is a dietary regimen characterized by low carbohydrate intake and moderate protein levels, designed to simulate a fasting state and induce ketosis for the production of ketone bodies from fat. Emerging research underscores KD’s potential in improving cognitive functions and regulating mood. Investigations into its safety and efficacy have centered on its anti-inflammatory properties and its impact on neurological health and the gut–brain axis (GBA). This review delves into the relationship between the KD and gut microbiota, emphasizing its potential role in cognitive enhancement and mood stabilization, particularly for managing mood disorders and depression. The investigation of the KD’s physiological effects and its role in promoting cognition and emotion through gut microbiota will pave the way for innovative approaches to personalized dietary interventions.https://www.mdpi.com/2304-8158/14/7/1215ketogenic dietgut microbiotadepressioncognitive impairment
spellingShingle Yuhan Jiang
Yili Chen
Youmeng Chen
Xinrong Gong
Zhiyu Chen
Xin Zhang
Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
Foods
ketogenic diet
gut microbiota
depression
cognitive impairment
title Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
title_full Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
title_fullStr Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
title_full_unstemmed Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
title_short Ketogenic Diet and Gut Microbiota: Exploring New Perspectives on Cognition and Mood
title_sort ketogenic diet and gut microbiota exploring new perspectives on cognition and mood
topic ketogenic diet
gut microbiota
depression
cognitive impairment
url https://www.mdpi.com/2304-8158/14/7/1215
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