Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization Strategies
Background: Various factors influence the immunologic responses to HBV vaccines in adults, including unchangeable individual characteristics. Personalized vaccination regimens accounting for host factors can enhance immune efficiency, particularly for adults at higher risk. Methods: In this two-cent...
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MDPI AG
2025-03-01
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| Series: | Vaccines |
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| author | Qian Qiu Huai Wang Wei Zhang |
| author_facet | Qian Qiu Huai Wang Wei Zhang |
| author_sort | Qian Qiu |
| collection | DOAJ |
| description | Background: Various factors influence the immunologic responses to HBV vaccines in adults, including unchangeable individual characteristics. Personalized vaccination regimens accounting for host factors can enhance immune efficiency, particularly for adults at higher risk. Methods: In this two-center controlled trial, HBV vaccine-naïve participants aged 25–55 were randomly administered the two types of HBV vaccines (yeast cell-derived (YDV) or Chinese hamster ovary (CHO) cell-derived) at 0–1–6 months. Antibody titers were measured eight weeks after the final dose. Results: Overall, 289 participants with YDV and 293 participants with CHO completed the three-dose series and antibody testing. The seroprotection rates (SPRs) were comparable (97.23% vs. 98.98%; <i>p</i> = 0.1398), but the geometric mean concentration (GMC) was significantly higher for the CHO (1627.83 mIU/mL vs. 600.76 mIU/mL; <i>p</i> < 0.0001). The GMC of both regimens declined significantly in individuals aged ≥45 years and males. Unlike the YDV, the GMC of CHO was minimally affected by BMI or smoking or drinking status. Conclusion: The CHO regimen may be advantageous for HBV vaccine-naïve adults aged 25–55 with BMI ≥ 25 or those who smoke or drink, in terms of immunogenicity and durability, providing insights for personalized immunization strategies. |
| format | Article |
| id | doaj-art-45589c222399441abbc21d77e7093034 |
| institution | OA Journals |
| issn | 2076-393X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Vaccines |
| spelling | doaj-art-45589c222399441abbc21d77e70930342025-08-20T01:50:07ZengMDPI AGVaccines2076-393X2025-03-0113329510.3390/vaccines13030295Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization StrategiesQian Qiu0Huai Wang1Wei Zhang2Beijing Center for Disease Prevention and Control, Beijing 100013, ChinaBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaBeijing Center for Disease Prevention and Control, Beijing 100013, ChinaBackground: Various factors influence the immunologic responses to HBV vaccines in adults, including unchangeable individual characteristics. Personalized vaccination regimens accounting for host factors can enhance immune efficiency, particularly for adults at higher risk. Methods: In this two-center controlled trial, HBV vaccine-naïve participants aged 25–55 were randomly administered the two types of HBV vaccines (yeast cell-derived (YDV) or Chinese hamster ovary (CHO) cell-derived) at 0–1–6 months. Antibody titers were measured eight weeks after the final dose. Results: Overall, 289 participants with YDV and 293 participants with CHO completed the three-dose series and antibody testing. The seroprotection rates (SPRs) were comparable (97.23% vs. 98.98%; <i>p</i> = 0.1398), but the geometric mean concentration (GMC) was significantly higher for the CHO (1627.83 mIU/mL vs. 600.76 mIU/mL; <i>p</i> < 0.0001). The GMC of both regimens declined significantly in individuals aged ≥45 years and males. Unlike the YDV, the GMC of CHO was minimally affected by BMI or smoking or drinking status. Conclusion: The CHO regimen may be advantageous for HBV vaccine-naïve adults aged 25–55 with BMI ≥ 25 or those who smoke or drink, in terms of immunogenicity and durability, providing insights for personalized immunization strategies.https://www.mdpi.com/2076-393X/13/3/295hepatitis B virusimmunizationadultsinfluencing factors |
| spellingShingle | Qian Qiu Huai Wang Wei Zhang Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization Strategies Vaccines hepatitis B virus immunization adults influencing factors |
| title | Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization Strategies |
| title_full | Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization Strategies |
| title_fullStr | Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization Strategies |
| title_full_unstemmed | Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization Strategies |
| title_short | Comparison of Yeast and CHO Cell-Derived Hepatitis B Vaccines and Influencing Factors in Vaccine-Naïve Adults in China: Insights for Personalized Immunization Strategies |
| title_sort | comparison of yeast and cho cell derived hepatitis b vaccines and influencing factors in vaccine naive adults in china insights for personalized immunization strategies |
| topic | hepatitis B virus immunization adults influencing factors |
| url | https://www.mdpi.com/2076-393X/13/3/295 |
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