In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer’s disease

In silico design of novel pyridazine derivatives as balanced multifunctional agents against Alzheimer’s disease

Abstract Alzheimer’s disease (AD) necessitates innovative therapeutic approaches that target its multifaceted pathology. This study investigates a series of 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as potential multi-target ligands for AD, aiming to simultaneously inhibit acet...

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Bibliographic Details
Main Authors: Mourad Aloui, Mohamed El fadili, Somdutt Mujwar, Mohammed Er-rajy, Hatem A. Abuelizz, Sara Er-rahmani, Sara Zarougui, Elhalaoui Menana
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
QSAR
Pyridazine
Molecular docking
Molecular dynamic
ADMET propriety
Alzheimer’s disease
Online Access:https://doi.org/10.1038/s41598-025-98182-x
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