The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models
Large-animal models are playing a pivotal role in bridging the translational research gap. Positron emission tomography (PET) imaging is preferred in disease research involving large-animal models. Its ability to non-invasively monitor metabolic activity, receptor–ligand interactions, and pharmacoki...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/7/919 |
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| author | Zhengyan Deng Peng Xi Dongye Zheng Zhaoheng Xie Xiangxi Meng Qiushi Ren |
| author_facet | Zhengyan Deng Peng Xi Dongye Zheng Zhaoheng Xie Xiangxi Meng Qiushi Ren |
| author_sort | Zhengyan Deng |
| collection | DOAJ |
| description | Large-animal models are playing a pivotal role in bridging the translational research gap. Positron emission tomography (PET) imaging is preferred in disease research involving large-animal models. Its ability to non-invasively monitor metabolic activity, receptor–ligand interactions, and pharmacokinetics in real time makes PET imaging an essential tool for evaluating therapeutic efficacy and advancing the development of targeted treatments. This review focuses on recent advancements in dedicated large-animal PET scanners, the utilization of large-animal models for simulating human diseases, and their applications in PET studies. It specifically highlights the critical role of PET imaging in facilitating the development of more effective and safer treatments for infections, chronic heart disease, diabetes, cancer, central nervous system disorders, and addiction, emphasizing its importance in the translational research landscape. |
| format | Article |
| id | doaj-art-455756eb9d0f4a28a99900deb280b7bb |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-455756eb9d0f4a28a99900deb280b7bb2025-08-20T03:07:57ZengMDPI AGBiomolecules2218-273X2025-06-0115791910.3390/biom15070919The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease ModelsZhengyan Deng0Peng Xi1Dongye Zheng2Zhaoheng Xie3Xiangxi Meng4Qiushi Ren5Department of Biomedical Engineering, College of Future Technology, Peking University, Beijing 100871, ChinaDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing 100871, ChinaDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing 100871, ChinaNational Biomedical Imaging Center, Peking University, Beijing 100871, ChinaNational Biomedical Imaging Center, Peking University, Beijing 100871, ChinaDepartment of Biomedical Engineering, College of Future Technology, Peking University, Beijing 100871, ChinaLarge-animal models are playing a pivotal role in bridging the translational research gap. Positron emission tomography (PET) imaging is preferred in disease research involving large-animal models. Its ability to non-invasively monitor metabolic activity, receptor–ligand interactions, and pharmacokinetics in real time makes PET imaging an essential tool for evaluating therapeutic efficacy and advancing the development of targeted treatments. This review focuses on recent advancements in dedicated large-animal PET scanners, the utilization of large-animal models for simulating human diseases, and their applications in PET studies. It specifically highlights the critical role of PET imaging in facilitating the development of more effective and safer treatments for infections, chronic heart disease, diabetes, cancer, central nervous system disorders, and addiction, emphasizing its importance in the translational research landscape.https://www.mdpi.com/2218-273X/15/7/919positron emission tomographylarge animalsneurologyinfectionmetabolic diseasecardiovascular imaging |
| spellingShingle | Zhengyan Deng Peng Xi Dongye Zheng Zhaoheng Xie Xiangxi Meng Qiushi Ren The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models Biomolecules positron emission tomography large animals neurology infection metabolic disease cardiovascular imaging |
| title | The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models |
| title_full | The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models |
| title_fullStr | The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models |
| title_full_unstemmed | The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models |
| title_short | The Impact of PET Imaging on Translational Medicine: Insights from Large-Animal Disease Models |
| title_sort | impact of pet imaging on translational medicine insights from large animal disease models |
| topic | positron emission tomography large animals neurology infection metabolic disease cardiovascular imaging |
| url | https://www.mdpi.com/2218-273X/15/7/919 |
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