Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus
Abstract Background The intracranial pressure (ICP) increases at night, partly due to an elevated rate of cerebrospinal fluid (CSF) secretion, which may have therapeutic implications for pressure-related disorders. With similar diurnal regulation in nocturnal rodents and diurnal humans, the diurnall...
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BMC
2025-06-01
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| Series: | Fluids and Barriers of the CNS |
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| Online Access: | https://doi.org/10.1186/s12987-025-00666-5 |
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| author | Beatriche L. Edelbo Annette B. Steffensen Eszter O. Revesz Søren N. Andreassen Nanna MacAulay |
| author_facet | Beatriche L. Edelbo Annette B. Steffensen Eszter O. Revesz Søren N. Andreassen Nanna MacAulay |
| author_sort | Beatriche L. Edelbo |
| collection | DOAJ |
| description | Abstract Background The intracranial pressure (ICP) increases at night, partly due to an elevated rate of cerebrospinal fluid (CSF) secretion, which may have therapeutic implications for pressure-related disorders. With similar diurnal regulation in nocturnal rodents and diurnal humans, the diurnally fluctuating CSF dynamics may be governed by nightly shifts in central neuromodulators. Method We determined the CSF secretion rate in rats upon modulation by melatonin, serotonin, and noradrenaline in association with transcript and protein analysis of choroid plexus receptors. Results The CSF secretion rate was unaffected by melatonin administration, but was reduced with central delivery of serotonin or noradrenaline. The latter produced only a brief surge in the CSF secretion rate upon systemic delivery. The neuromodulators may thus act on the luminal side of the choroid plexus on the selection of serotonergic and adrenergic receptors expressed in this tissue, some of which displayed diurnal regulation. Conclusion Diurnally fluctuating central serotonin and noradrenaline levels and/or diurnal fluctuation in choroid plexus adrenergic receptor expression may contribute to the diurnal shift in human and rodent CSF secretion rate. These signaling pathways could thus potentially be harnessed to create pharmacological modulation of the CSF secretion rate in pathological conditions of elevated ICP. |
| format | Article |
| id | doaj-art-4555ff668c2247a186486ff57622c65e |
| institution | DOAJ |
| issn | 2045-8118 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Fluids and Barriers of the CNS |
| spelling | doaj-art-4555ff668c2247a186486ff57622c65e2025-08-20T03:10:35ZengBMCFluids and Barriers of the CNS2045-81182025-06-0122111210.1186/s12987-025-00666-5Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexusBeatriche L. Edelbo0Annette B. Steffensen1Eszter O. Revesz2Søren N. Andreassen3Nanna MacAulay4Department of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenDepartment of Neuroscience, Faculty of Health and Medical Sciences, University of CopenhagenAbstract Background The intracranial pressure (ICP) increases at night, partly due to an elevated rate of cerebrospinal fluid (CSF) secretion, which may have therapeutic implications for pressure-related disorders. With similar diurnal regulation in nocturnal rodents and diurnal humans, the diurnally fluctuating CSF dynamics may be governed by nightly shifts in central neuromodulators. Method We determined the CSF secretion rate in rats upon modulation by melatonin, serotonin, and noradrenaline in association with transcript and protein analysis of choroid plexus receptors. Results The CSF secretion rate was unaffected by melatonin administration, but was reduced with central delivery of serotonin or noradrenaline. The latter produced only a brief surge in the CSF secretion rate upon systemic delivery. The neuromodulators may thus act on the luminal side of the choroid plexus on the selection of serotonergic and adrenergic receptors expressed in this tissue, some of which displayed diurnal regulation. Conclusion Diurnally fluctuating central serotonin and noradrenaline levels and/or diurnal fluctuation in choroid plexus adrenergic receptor expression may contribute to the diurnal shift in human and rodent CSF secretion rate. These signaling pathways could thus potentially be harnessed to create pharmacological modulation of the CSF secretion rate in pathological conditions of elevated ICP.https://doi.org/10.1186/s12987-025-00666-5CSFDiurnalICPChoroid plexusNoradrenaline |
| spellingShingle | Beatriche L. Edelbo Annette B. Steffensen Eszter O. Revesz Søren N. Andreassen Nanna MacAulay Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus Fluids and Barriers of the CNS CSF Diurnal ICP Choroid plexus Noradrenaline |
| title | Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus |
| title_full | Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus |
| title_fullStr | Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus |
| title_full_unstemmed | Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus |
| title_short | Modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus |
| title_sort | modulation of cerebrospinal fluid secretion facilitated by serotonergic and noradrenergic receptors in the rat choroid plexus |
| topic | CSF Diurnal ICP Choroid plexus Noradrenaline |
| url | https://doi.org/10.1186/s12987-025-00666-5 |
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