Enhancing Akkermansia growth via phytohormones: a strategy to modulate the gut-bone axis in postmenopausal osteoporosis therapy

Enhancing Akkermansia growth via phytohormones: a strategy to modulate the gut-bone axis in postmenopausal osteoporosis therapy

Abstract Background Phytohormones have garnered considerable interest as potential modulators of the gut-bone axis. Denosumab (Deno), a widely utilized therapeutic agent for postmenopausal osteoporosis, has not been previously investigated for its effects on gut health. The objective of this study w...

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Bibliographic Details
Main Authors: Zhiqi Zhao, Yixuan Deng, Li Li, Liying Zhu, Xin Wang, Haibiao Sun, Xiaoqiong Li, Xiaoqiang Han, Jinjun Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Osteoporosis
Phytohormones
Soybean isoflavone
Naringin
Denosumab
Gut microbiome
Online Access:https://doi.org/10.1186/s12967-025-06426-1
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