Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi
Objective: To evaluate the correlation between changes in serum liver function tests and the severity of dengue fever. Study Design: Cross-sectional study. Place and Duration of Study: This study was conducted at the Department of Medicine, Pak Emirates Military Hospital, from 1st May 2023 till 30th...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
National University of Medical Sciences
2025-01-01
|
| Series: | Life and Science |
| Subjects: | |
| Online Access: | https://ojs.lifenscience.org/index.php/life-and-science/article/view/709 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850048228090707968 |
|---|---|
| author | Waleed Ur Rehman Muhammad Zafar Ali Abdul Rehman Arshad Muhammad Iqbal Nauman Karim Muttahar Abbas Zubair Ahmed |
| author_facet | Waleed Ur Rehman Muhammad Zafar Ali Abdul Rehman Arshad Muhammad Iqbal Nauman Karim Muttahar Abbas Zubair Ahmed |
| author_sort | Waleed Ur Rehman |
| collection | DOAJ |
| description | Objective: To evaluate the correlation between changes in serum liver function tests and the severity of dengue fever.
Study Design: Cross-sectional study.
Place and Duration of Study: This study was conducted at the Department of Medicine, Pak Emirates Military Hospital, from 1st May 2023 till 30th October 2023.
Methods: Patients aged 18 years and above who had dengue NS1 rapid test assay or dengue IgM/IgG rapid test positive were included in the study using convenience sampling. Participants with pre-existing liver conditions, chronic kidney disease, pregnant women, and those with concurrent infectious illness were excluded. The World Health Organization classification system was used to classify the patient’s disease severity into Dengue Fever and Severe dengue.
Results: One hundred and seventy-one patients, including 131 (76.61%) males, had a mean age of 35.91±12.86 years. Severe dengue was observed in 15 (8.8%), while 156 (91.2%) had dengue fever. The dengue NS1 protein assay was positive in 169 (98.8%) and dengue serology was positive only in 2 (1.2%). All liver enzymes, including serum alanine transaminase, serum alkaline phosphatase, serum albumin, and serum bilirubin, had significant relation amongst the dengue disease severity groups. The severity of hepatic impairment was also significantly related to the World Health Organization classification (P = 0.02).
Conclusion: Dengue fever severity can be predicted early by derangements in liver function tests as they statistically correlate with the severity of the disease.
How to cite this: Rehman W, Ali MZ, Arshad AR, Iqbal M, Karim N, Abbas M, Ahmed Z. Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi. Life and Science. 2025; 6(1): 95-101. doi: http://doi.org/10.37185/LnS.1.1.709 |
| format | Article |
| id | doaj-art-45521fd7f5c14dd49bfca9cbe86fdd91 |
| institution | DOAJ |
| issn | 2521-0475 2708-2970 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | National University of Medical Sciences |
| record_format | Article |
| series | Life and Science |
| spelling | doaj-art-45521fd7f5c14dd49bfca9cbe86fdd912025-08-20T02:54:01ZengNational University of Medical SciencesLife and Science2521-04752708-29702025-01-0161070710.37185/LnS.1.1.709709Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, RawalpindiWaleed Ur Rehman0Muhammad Zafar Ali1Abdul Rehman Arshad2Muhammad Iqbal3Nauman Karim4Muttahar Abbas5Zubair Ahmed6Pak Emirates Military Hospital (PEMH) Rawalpindi, PakistanPak Emirates Military Hospital (PEMH) Rawalpindi, PakistanPak Emirates Military Hospital (PEMH) Rawalpindi, PakistanPak Emirates Military Hospital (PEMH) Rawalpindi, PakistanPak Emirates Military Hospital (PEMH) Rawalpindi, PakistanPak Emirates Military Hospital (PEMH) Rawalpindi, PakistanPak Emirates Military Hospital (PEMH) Rawalpindi, PakistanObjective: To evaluate the correlation between changes in serum liver function tests and the severity of dengue fever. Study Design: Cross-sectional study. Place and Duration of Study: This study was conducted at the Department of Medicine, Pak Emirates Military Hospital, from 1st May 2023 till 30th October 2023. Methods: Patients aged 18 years and above who had dengue NS1 rapid test assay or dengue IgM/IgG rapid test positive were included in the study using convenience sampling. Participants with pre-existing liver conditions, chronic kidney disease, pregnant women, and those with concurrent infectious illness were excluded. The World Health Organization classification system was used to classify the patient’s disease severity into Dengue Fever and Severe dengue. Results: One hundred and seventy-one patients, including 131 (76.61%) males, had a mean age of 35.91±12.86 years. Severe dengue was observed in 15 (8.8%), while 156 (91.2%) had dengue fever. The dengue NS1 protein assay was positive in 169 (98.8%) and dengue serology was positive only in 2 (1.2%). All liver enzymes, including serum alanine transaminase, serum alkaline phosphatase, serum albumin, and serum bilirubin, had significant relation amongst the dengue disease severity groups. The severity of hepatic impairment was also significantly related to the World Health Organization classification (P = 0.02). Conclusion: Dengue fever severity can be predicted early by derangements in liver function tests as they statistically correlate with the severity of the disease. How to cite this: Rehman W, Ali MZ, Arshad AR, Iqbal M, Karim N, Abbas M, Ahmed Z. Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi. Life and Science. 2025; 6(1): 95-101. doi: http://doi.org/10.37185/LnS.1.1.709https://ojs.lifenscience.org/index.php/life-and-science/article/view/709aedes-borne diseases, dengue fever, hepatitis, liver, liver dysfunction |
| spellingShingle | Waleed Ur Rehman Muhammad Zafar Ali Abdul Rehman Arshad Muhammad Iqbal Nauman Karim Muttahar Abbas Zubair Ahmed Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi Life and Science aedes-borne diseases, dengue fever, hepatitis, liver, liver dysfunction |
| title | Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi |
| title_full | Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi |
| title_fullStr | Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi |
| title_full_unstemmed | Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi |
| title_short | Correlation Between Liver Function Test and Severity of Dengue Fever at a Tertiary Care Hospital, Rawalpindi |
| title_sort | correlation between liver function test and severity of dengue fever at a tertiary care hospital rawalpindi |
| topic | aedes-borne diseases, dengue fever, hepatitis, liver, liver dysfunction |
| url | https://ojs.lifenscience.org/index.php/life-and-science/article/view/709 |
| work_keys_str_mv | AT waleedurrehman correlationbetweenliverfunctiontestandseverityofdenguefeveratatertiarycarehospitalrawalpindi AT muhammadzafarali correlationbetweenliverfunctiontestandseverityofdenguefeveratatertiarycarehospitalrawalpindi AT abdulrehmanarshad correlationbetweenliverfunctiontestandseverityofdenguefeveratatertiarycarehospitalrawalpindi AT muhammadiqbal correlationbetweenliverfunctiontestandseverityofdenguefeveratatertiarycarehospitalrawalpindi AT naumankarim correlationbetweenliverfunctiontestandseverityofdenguefeveratatertiarycarehospitalrawalpindi AT muttaharabbas correlationbetweenliverfunctiontestandseverityofdenguefeveratatertiarycarehospitalrawalpindi AT zubairahmed correlationbetweenliverfunctiontestandseverityofdenguefeveratatertiarycarehospitalrawalpindi |