The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats
Magnesium sulfate (MgSO4) has been used to prevent seizures in eclampsia. This study examined the central effects of MgSO4 on different types of pentylenetetrazole (PTZ)-induced seizures. Male Wistar rats were submitted to intracerebroventricular (ICV) administration of MgSO4 at different doses foll...
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Thieme Revinter Publicações
2011-01-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000300016&lng=en&tlng=en |
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| author | L D B Oliveira R W D Oliveira H A Futuro Neto E M Nakamura-Palacios |
| author_facet | L D B Oliveira R W D Oliveira H A Futuro Neto E M Nakamura-Palacios |
| author_sort | L D B Oliveira |
| collection | DOAJ |
| description | Magnesium sulfate (MgSO4) has been used to prevent seizures in eclampsia. This study examined the central effects of MgSO4 on different types of pentylenetetrazole (PTZ)-induced seizures. Male Wistar rats were submitted to intracerebroventricular (ICV) administration of MgSO4 at different doses followed by intraperitoneal administration of PTZ. The latency to the onset of the first seizure induced by PTZ was significantly increased by ICV administration of MgSO4 at a dose of 100 µg compared to the control treatment. In addition, the total period during which animals presented with seizures was significantly reduced at this dose of MgSO4. Furthermore, the latency to the onset of the first partial complex seizure was significantly increased by the lowest dose of MgSO4. However, a high dose of MgSO4 had no effect or even potentiated the effect of PTZ. These results suggest that, depending on the dose, MgSO4 may be important in prevention of epileptic seizures. |
| format | Article |
| id | doaj-art-454e96971b17456ebde7c8bb641cc3bd |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-454e96971b17456ebde7c8bb641cc3bd2025-08-20T03:36:44ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272011-01-01692b34935510.1590/S0004-282X2011000300016S0004-282X2011000300016The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in ratsL D B Oliveira0R W D Oliveira1H A Futuro Neto2E M Nakamura-Palacios3Universidade Federal do Espírito SantoUniversidade Federal do Espírito SantoSanta Casa de Misericórdia de VitóriaUniversidade Federal do Espírito SantoMagnesium sulfate (MgSO4) has been used to prevent seizures in eclampsia. This study examined the central effects of MgSO4 on different types of pentylenetetrazole (PTZ)-induced seizures. Male Wistar rats were submitted to intracerebroventricular (ICV) administration of MgSO4 at different doses followed by intraperitoneal administration of PTZ. The latency to the onset of the first seizure induced by PTZ was significantly increased by ICV administration of MgSO4 at a dose of 100 µg compared to the control treatment. In addition, the total period during which animals presented with seizures was significantly reduced at this dose of MgSO4. Furthermore, the latency to the onset of the first partial complex seizure was significantly increased by the lowest dose of MgSO4. However, a high dose of MgSO4 had no effect or even potentiated the effect of PTZ. These results suggest that, depending on the dose, MgSO4 may be important in prevention of epileptic seizures.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000300016&lng=en&tlng=ensulfato de magnésiocrises epilépticasmodelos experimentaisPTZratos |
| spellingShingle | L D B Oliveira R W D Oliveira H A Futuro Neto E M Nakamura-Palacios The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats Arquivos de Neuro-Psiquiatria sulfato de magnésio crises epilépticas modelos experimentais PTZ ratos |
| title | The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats |
| title_full | The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats |
| title_fullStr | The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats |
| title_full_unstemmed | The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats |
| title_short | The role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats |
| title_sort | role of magnesium sulfate in prevention of seizures induced by pentylenetetrazole in rats |
| topic | sulfato de magnésio crises epilépticas modelos experimentais PTZ ratos |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2011000300016&lng=en&tlng=en |
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