Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report
Acute lymphoblastic leukemia is predominantly found in children. It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage. The immature cells in B-acute lymphoblastic leukemia/lymphoma can be small or medium sized with scant or moderate cytoplasm and typically e...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2013/679892 |
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| author | Alicia C. Hirzel Aaron Cotrell Robert Gasparini Vathany Sriganeshan |
| author_facet | Alicia C. Hirzel Aaron Cotrell Robert Gasparini Vathany Sriganeshan |
| author_sort | Alicia C. Hirzel |
| collection | DOAJ |
| description | Acute lymphoblastic leukemia is predominantly found in children. It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage. The immature cells in B-acute lymphoblastic leukemia/lymphoma can be small or medium sized with scant or moderate cytoplasm and typically express B-cell markers such as CD19, cytoplasmic CD79a, and TdT without surface light chains. These markers, along with cytogenetic studies, are vital to the diagnosis, classification, and treatment of these neoplasms. We present an unusual case of a precursor B-cell ALL, in an 82-year-old woman, who presented with pancytopenia and widespread lymphadenopathy. The cells show L3 morphology (Burkitt-like lymphoma) with coexpression of TdT and surface light chains in addition to an MYC gene translocation and Philadelphia chromosome. |
| format | Article |
| id | doaj-art-4549e8aa1e8d46f7b79202fbfda52c25 |
| institution | OA Journals |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-4549e8aa1e8d46f7b79202fbfda52c252025-08-20T02:37:52ZengWileyCase Reports in Pathology2090-67812090-679X2013-01-01201310.1155/2013/679892679892Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case ReportAlicia C. Hirzel0Aaron Cotrell1Robert Gasparini2Vathany Sriganeshan3Mount Sinai Medical Center, A.M. Rywlin, Department of Pathology and Laboratory Medicine, 4300 Alton Road, Suite 2200, Miami Beach, FL 33140, USAMount Sinai Medical Center, A.M. Rywlin, Department of Pathology and Laboratory Medicine, 4300 Alton Road, Suite 2200, Miami Beach, FL 33140, USANeogenomics Laboratories, 12701 Commonwealth Drive, Fort Myers, FL 33913, USAMount Sinai Medical Center, A.M. Rywlin, Department of Pathology and Laboratory Medicine, 4300 Alton Road, Suite 2200, Miami Beach, FL 33140, USAAcute lymphoblastic leukemia is predominantly found in children. It is a neoplasm of precursor cells or lymphoblasts committed to either a B- or T-cell lineage. The immature cells in B-acute lymphoblastic leukemia/lymphoma can be small or medium sized with scant or moderate cytoplasm and typically express B-cell markers such as CD19, cytoplasmic CD79a, and TdT without surface light chains. These markers, along with cytogenetic studies, are vital to the diagnosis, classification, and treatment of these neoplasms. We present an unusual case of a precursor B-cell ALL, in an 82-year-old woman, who presented with pancytopenia and widespread lymphadenopathy. The cells show L3 morphology (Burkitt-like lymphoma) with coexpression of TdT and surface light chains in addition to an MYC gene translocation and Philadelphia chromosome.http://dx.doi.org/10.1155/2013/679892 |
| spellingShingle | Alicia C. Hirzel Aaron Cotrell Robert Gasparini Vathany Sriganeshan Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report Case Reports in Pathology |
| title | Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report |
| title_full | Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report |
| title_fullStr | Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report |
| title_full_unstemmed | Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report |
| title_short | Precursor B-Cell Acute Lymphoblastic Leukemia/Lymphoma with L3 Morphology, Philadelphia Chromosome, MYC Gene Translocation, and Coexpression of TdT and Surface Light Chains: A Case Report |
| title_sort | precursor b cell acute lymphoblastic leukemia lymphoma with l3 morphology philadelphia chromosome myc gene translocation and coexpression of tdt and surface light chains a case report |
| url | http://dx.doi.org/10.1155/2013/679892 |
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