Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary
IntroductionDue to risk and response-adapted treatment strategies, more than 80% of newly diagnosed adult classical Hodgkin lymphoma (HL) patients at any stage can be cured and become long-term survivors. A well-known side effect is cognitive dysfunction that appears in HL patients after chemotherap...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1509424/full |
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| author | István Virga István Virga Karolina Kósa Anna Illés Zsófia Miltényi Zsófia Miltényi Tibor Ivánka Roland Berecz Anikó Égerházi Árpád Illés Árpád Illés Ferenc Magyari Ferenc Magyari |
| author_facet | István Virga István Virga Karolina Kósa Anna Illés Zsófia Miltényi Zsófia Miltényi Tibor Ivánka Roland Berecz Anikó Égerházi Árpád Illés Árpád Illés Ferenc Magyari Ferenc Magyari |
| author_sort | István Virga |
| collection | DOAJ |
| description | IntroductionDue to risk and response-adapted treatment strategies, more than 80% of newly diagnosed adult classical Hodgkin lymphoma (HL) patients at any stage can be cured and become long-term survivors. A well-known side effect is cognitive dysfunction that appears in HL patients after chemotherapy (chemobrain). In the present longitudinal study, we measured cognitive function in our HL patients, in search of potential correlations between patient-related factors, the signs and symptoms of their diseases, and therapeutic factors.MethodsPatients underwent a computer-assisted assessment (CANTAB) of cognitive function (especially domains of visual memory, attention, working memory, and planning) and filled out psychological questionnaires (standardized, self-administered and validated for Hungarian language) before treatment (n=30, T1) and after the first-line treatment (n=25, T2), and 8.6 years after the end of chemotherapy (n=19, T3).ResultsThe median age of 16 females and 14 males was 35 years (20-69), 35 years (21-63) after chemotherapy, and 43 years (29-70) at the end of the long-term follow-up, when the study was completed. 77% of all patients showed cognitive impairment before treatment. A close correlation was found between attention and unfavorable prognostic factors (III-IV. stage, age, bulky) baseline comorbidities (T2DM, psoriasis, HTN) and place of residence. Visual memory was affected by comorbidities and the place of residence. Working memory and planning was influenced by single marital status, and bulk disease. Post-treatment cognitive impairment was evaluated in 77% of the HL patients. In the working memory and planning domain, the Stockings of Cambridge (SOC) subtest significantly improved after treatment, while visual memory and attention remained unchanged. The cumulative dose of bleomycin associated with SOC.ConclusionThe study highlights the fact that cognitive functions of HL patients were already impaired before treatment, especially attention, working memory, and planning. Long-term improvement in cognitive function was observed post-treatment. Employment status, place of residence and unfavorable prognosis have an impact on cognitive domains. Early diagnosis and intervention are essential to maintain patients’ quality of life throughout and after treatment. |
| format | Article |
| id | doaj-art-4548db28e05c4e6b9804d8f83e5b9dd0 |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-4548db28e05c4e6b9804d8f83e5b9dd02025-08-20T02:13:20ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.15094241509424Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in HungaryIstván Virga0István Virga1Karolina Kósa2Anna Illés3Zsófia Miltényi4Zsófia Miltényi5Tibor Ivánka6Roland Berecz7Anikó Égerházi8Árpád Illés9Árpád Illés10Ferenc Magyari11Ferenc Magyari12Division of Haematology, Department of Internal Medicine, University of Debrecen, Debrecen, HungaryDoctoral School of Clinical Medicine, University of Debrecen, Debrecen, HungaryDepartment of Anesthesiology and Intensive Care, University of Debrecen, Debrecen, HungaryDepartment of Behavioral Sciences, University of Debrecen, Debrecen, HungaryDivision of Haematology, Department of Internal Medicine, University of Debrecen, Debrecen, HungaryDoctoral School of Clinical Medicine, University of Debrecen, Debrecen, HungaryDepartment of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDepartment of Psychiatry, Faculty of Medicine, University of Debrecen, Debrecen, HungaryDivision of Haematology, Department of Internal Medicine, University of Debrecen, Debrecen, HungaryDoctoral School of Clinical Medicine, University of Debrecen, Debrecen, HungaryDivision of Haematology, Department of Internal Medicine, University of Debrecen, Debrecen, HungaryDoctoral School of Clinical Medicine, University of Debrecen, Debrecen, HungaryIntroductionDue to risk and response-adapted treatment strategies, more than 80% of newly diagnosed adult classical Hodgkin lymphoma (HL) patients at any stage can be cured and become long-term survivors. A well-known side effect is cognitive dysfunction that appears in HL patients after chemotherapy (chemobrain). In the present longitudinal study, we measured cognitive function in our HL patients, in search of potential correlations between patient-related factors, the signs and symptoms of their diseases, and therapeutic factors.MethodsPatients underwent a computer-assisted assessment (CANTAB) of cognitive function (especially domains of visual memory, attention, working memory, and planning) and filled out psychological questionnaires (standardized, self-administered and validated for Hungarian language) before treatment (n=30, T1) and after the first-line treatment (n=25, T2), and 8.6 years after the end of chemotherapy (n=19, T3).ResultsThe median age of 16 females and 14 males was 35 years (20-69), 35 years (21-63) after chemotherapy, and 43 years (29-70) at the end of the long-term follow-up, when the study was completed. 77% of all patients showed cognitive impairment before treatment. A close correlation was found between attention and unfavorable prognostic factors (III-IV. stage, age, bulky) baseline comorbidities (T2DM, psoriasis, HTN) and place of residence. Visual memory was affected by comorbidities and the place of residence. Working memory and planning was influenced by single marital status, and bulk disease. Post-treatment cognitive impairment was evaluated in 77% of the HL patients. In the working memory and planning domain, the Stockings of Cambridge (SOC) subtest significantly improved after treatment, while visual memory and attention remained unchanged. The cumulative dose of bleomycin associated with SOC.ConclusionThe study highlights the fact that cognitive functions of HL patients were already impaired before treatment, especially attention, working memory, and planning. Long-term improvement in cognitive function was observed post-treatment. Employment status, place of residence and unfavorable prognosis have an impact on cognitive domains. Early diagnosis and intervention are essential to maintain patients’ quality of life throughout and after treatment.https://www.frontiersin.org/articles/10.3389/fonc.2025.1509424/fullHodgkin-lymphomacancer-related cognitive impairment (CRCI)computerized neuropsychological test battery (CANTAB)health-related quality of lifechemobrain |
| spellingShingle | István Virga István Virga Karolina Kósa Anna Illés Zsófia Miltényi Zsófia Miltényi Tibor Ivánka Roland Berecz Anikó Égerházi Árpád Illés Árpád Illés Ferenc Magyari Ferenc Magyari Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary Frontiers in Oncology Hodgkin-lymphoma cancer-related cognitive impairment (CRCI) computerized neuropsychological test battery (CANTAB) health-related quality of life chemobrain |
| title | Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary |
| title_full | Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary |
| title_fullStr | Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary |
| title_full_unstemmed | Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary |
| title_short | Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary |
| title_sort | longitudinal study of cognitive and mental functions among adult hodgkin lymphoma survivors based on data from a primary treatment center in hungary |
| topic | Hodgkin-lymphoma cancer-related cognitive impairment (CRCI) computerized neuropsychological test battery (CANTAB) health-related quality of life chemobrain |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1509424/full |
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