Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile
Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity. DIN occurring in the anus is quit...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2019/2301640 |
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| author | Caroline Koopmansch Calliope Maris Pieter Demetter Jean Van de Stadt Alain Hendlisz Nicky D’Haene Jean-Christophe Noël |
| author_facet | Caroline Koopmansch Calliope Maris Pieter Demetter Jean Van de Stadt Alain Hendlisz Nicky D’Haene Jean-Christophe Noël |
| author_sort | Caroline Koopmansch |
| collection | DOAJ |
| description | Differentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity. DIN occurring in the anus is quite rare, and to the best of our knowledge, only one publication reported it. In this report, we describe the clinicopathological features of this entity on anal margin, associated with invasive squamous cell carcinoma. In addition, using the next generation sequencing (NGS) technique, we have demonstrated TP53 mutation in the invasive component but not in the associated DIN-like lesion, where p53 immunohistochemical expression was restricted to basal layers. |
| format | Article |
| id | doaj-art-453007b263bc44398c7e09aa5a7cf4f3 |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-453007b263bc44398c7e09aa5a7cf4f32025-08-20T03:36:44ZengWileyCase Reports in Pathology2090-67812090-679X2019-01-01201910.1155/2019/23016402301640Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular ProfileCaroline Koopmansch0Calliope Maris1Pieter Demetter2Jean Van de Stadt3Alain Hendlisz4Nicky D’Haene5Jean-Christophe Noël6Department of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, BelgiumDepartment of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, BelgiumDepartment of Pathology, Jules Bordet Institute, Free University of Brussels (ULB), Brussels, BelgiumDepartment of Digestive Surgery, Erasme University Hospital, Free University of Brussels (ULB), Brussels, BelgiumDigestive Oncology Unit, Medicine Department, Jules Bordet Institute, Free University of Brussels (ULB), Brussels, BelgiumDepartment of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, BelgiumDepartment of Pathology, Erasme University Hospital, Free University of Brussels (ULB), Brussels, BelgiumDifferentiated-type Intraepithelial Neoplasia (DIN) is defined as HPV-negative squamous intraepithelial proliferation with abnormal keratinocyte differentiation and basal cell atypia, originally described in the vulva, with following descriptions in the oral cavity. DIN occurring in the anus is quite rare, and to the best of our knowledge, only one publication reported it. In this report, we describe the clinicopathological features of this entity on anal margin, associated with invasive squamous cell carcinoma. In addition, using the next generation sequencing (NGS) technique, we have demonstrated TP53 mutation in the invasive component but not in the associated DIN-like lesion, where p53 immunohistochemical expression was restricted to basal layers.http://dx.doi.org/10.1155/2019/2301640 |
| spellingShingle | Caroline Koopmansch Calliope Maris Pieter Demetter Jean Van de Stadt Alain Hendlisz Nicky D’Haene Jean-Christophe Noël Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile Case Reports in Pathology |
| title | Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile |
| title_full | Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile |
| title_fullStr | Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile |
| title_full_unstemmed | Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile |
| title_short | Differentiated-Type Intraepithelial Neoplasia-Like Lesion Associated with Squamous Cell Carcinoma of the Anus: A Case Report with Molecular Profile |
| title_sort | differentiated type intraepithelial neoplasia like lesion associated with squamous cell carcinoma of the anus a case report with molecular profile |
| url | http://dx.doi.org/10.1155/2019/2301640 |
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