Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia
Abstract Positive symptoms are a prominent feature of schizophrenia. Despite antipsychotic treatment, ~30% of patients develop refractory positive symptoms (RPSs). Current research fails to elucidate the potential neurophysiological mechanisms underlying RPSs, thereby hindering the development of ad...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-07-01
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| Series: | Schizophrenia |
| Online Access: | https://doi.org/10.1038/s41537-025-00652-8 |
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| _version_ | 1849333388743278592 |
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| author | Xiaojuan Wang Sitong Chen Jie Li Ying Gao Shaobing Li Meijuan Li Xiaoya Liu Shuang Liu Dong Ming |
| author_facet | Xiaojuan Wang Sitong Chen Jie Li Ying Gao Shaobing Li Meijuan Li Xiaoya Liu Shuang Liu Dong Ming |
| author_sort | Xiaojuan Wang |
| collection | DOAJ |
| description | Abstract Positive symptoms are a prominent feature of schizophrenia. Despite antipsychotic treatment, ~30% of patients develop refractory positive symptoms (RPSs). Current research fails to elucidate the potential neurophysiological mechanisms underlying RPSs, thereby hindering the development of additional treatments. This study, which included 37 patients with RPSs and 40 with non-refractory positive symptoms (NRPSs), aimed to explore their underlying neural mechanisms. Outcome measures were relative power spectrum density and interregional synchronization across frequency bands and theta-gamma phase-amplitude coupling (θ-γ PAC). The single-frequency analysis indicated that RPSs exhibited elevated theta power and reduced lateralization in the left temporal lobe and temporo-parietal junction, along with enhanced functional connectivity in the left frontocentral region. The cross-frequency analysis revealed that RPSs exhibited slightly higher θ-γ coupling at the left temporo-parietal junction compared to NRPSs. Correlation analysis revealed significant associations among theta power, the lateralization index, functional connectivity, and the severity of positive symptoms. The aberrant activation of the theta rhythm in the left temporo-parietal region may lead to increased functional asymmetry in the brain, impeding interregional and inter-frequency information transmission and thus significantly impairing the normal processing of auditory information. These findings offer potential insights into the neurophysiological basis of positive symptoms in schizophrenia and may inform future clinical interventions. |
| format | Article |
| id | doaj-art-452ce064ec4f4b09bf8be53bfdf37280 |
| institution | Kabale University |
| issn | 2754-6993 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Schizophrenia |
| spelling | doaj-art-452ce064ec4f4b09bf8be53bfdf372802025-08-20T03:45:52ZengNature PortfolioSchizophrenia2754-69932025-07-011111910.1038/s41537-025-00652-8Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophreniaXiaojuan Wang0Sitong Chen1Jie Li2Ying Gao3Shaobing Li4Meijuan Li5Xiaoya Liu6Shuang Liu7Dong Ming8Academy of Medical Engineering and Translational Medicine, Tianjin UniversityAcademy of Medical Engineering and Translational Medicine, Tianjin UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityInstitute of Mental Health, Tianjin Anding Hospital, Mental Health Center of Tianjin Medical UniversityAcademy of Medical Engineering and Translational Medicine, Tianjin UniversityAcademy of Medical Engineering and Translational Medicine, Tianjin UniversityAcademy of Medical Engineering and Translational Medicine, Tianjin UniversityAbstract Positive symptoms are a prominent feature of schizophrenia. Despite antipsychotic treatment, ~30% of patients develop refractory positive symptoms (RPSs). Current research fails to elucidate the potential neurophysiological mechanisms underlying RPSs, thereby hindering the development of additional treatments. This study, which included 37 patients with RPSs and 40 with non-refractory positive symptoms (NRPSs), aimed to explore their underlying neural mechanisms. Outcome measures were relative power spectrum density and interregional synchronization across frequency bands and theta-gamma phase-amplitude coupling (θ-γ PAC). The single-frequency analysis indicated that RPSs exhibited elevated theta power and reduced lateralization in the left temporal lobe and temporo-parietal junction, along with enhanced functional connectivity in the left frontocentral region. The cross-frequency analysis revealed that RPSs exhibited slightly higher θ-γ coupling at the left temporo-parietal junction compared to NRPSs. Correlation analysis revealed significant associations among theta power, the lateralization index, functional connectivity, and the severity of positive symptoms. The aberrant activation of the theta rhythm in the left temporo-parietal region may lead to increased functional asymmetry in the brain, impeding interregional and inter-frequency information transmission and thus significantly impairing the normal processing of auditory information. These findings offer potential insights into the neurophysiological basis of positive symptoms in schizophrenia and may inform future clinical interventions.https://doi.org/10.1038/s41537-025-00652-8 |
| spellingShingle | Xiaojuan Wang Sitong Chen Jie Li Ying Gao Shaobing Li Meijuan Li Xiaoya Liu Shuang Liu Dong Ming Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia Schizophrenia |
| title | Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia |
| title_full | Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia |
| title_fullStr | Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia |
| title_full_unstemmed | Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia |
| title_short | Enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia |
| title_sort | enhanced theta oscillations in the left temporoparietal region associated with refractory positive symptoms in schizophrenia |
| url | https://doi.org/10.1038/s41537-025-00652-8 |
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