Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway

Ubiquitin specific peptidase 11 knockdown slows Huntington’s disease progression via regulating mitochondrial dysfunction and neuronal damage depending on PTEN-mediated AKT pathway

Abstract Background Mitochondrial dysfunction and neuronal damage are major sign of cytopathology in Huntington’s disease (HD), a neurodegenerative disease. Ubiquitin specific peptidase 11 (USP11) is a deubiquitinating enzyme involved in various physiological processes through regulating protein deg...

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Bibliographic Details
Main Authors: Bai Gao, Yuchen Jing, Xi Li, Shuyan Cong
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Molecular Medicine
Subjects:
Huntington’s disease (HD)
Ubiquitin specific peptidase 11 (USP11)
Phosphatase and tensin homolog (PTEN)
Neuronal apoptosis
Mitochondria
Online Access:https://doi.org/10.1186/s10020-024-01061-w
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https://doi.org/10.1186/s10020-024-01061-w

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