Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo

Osteosarcoma cells depend on MCL-1 for survival, and osteosarcoma metastases respond to MCL-1 antagonism plus regorafenib in vivo

Abstract Osteosarcoma is the most common form of primary bone cancer, which primarily afflicts children and adolescents. Chemotherapy, consisting of doxorubicin, cisplatin and methotrexate (MAP) increased the 5-year osteosarcoma survival rate from 20% to approximately 60% by the 1980s. However, oste...

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Bibliographic Details
Main Authors: Yanhao Ji, Michael A. Harris, Lucas M. Newton, Tiffany J. Harris, W. Douglas Fairlie, Erinna F. Lee, Christine J. Hawkins
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Cancer
Subjects:
Osteosarcoma
Sarcoma
BH3-mimetic
MCL-1
BCL-xL
Kinase inhibitor
Online Access:https://doi.org/10.1186/s12885-024-13088-7
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