Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population
Objectives This study aimed to investigate the dynamic trends in total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels with ageing.Design A Chinese population-based cross-sectional study.Setting A physical exami...
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BMJ Publishing Group
2020-03-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/10/3/e034226.full |
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| author | Ying Zhu Ying Li Xuan Luo Shiyan Nian Zongwu Tong Chunting Zhang Xuejing Bai Mengna Wu Zefeng Yan |
| author_facet | Ying Zhu Ying Li Xuan Luo Shiyan Nian Zongwu Tong Chunting Zhang Xuejing Bai Mengna Wu Zefeng Yan |
| author_sort | Ying Zhu |
| collection | DOAJ |
| description | Objectives This study aimed to investigate the dynamic trends in total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels with ageing.Design A Chinese population-based cross-sectional study.Setting A physical examination centre of a general hospital.Participants Adult subjects (178 167: 103 461 men and 74 706 women) without a known medical history or treatments that affect lipid metabolism.Main outcome measures Dynamic trends in the above-mentioned lipid parameters with ageing were explored; turning points of age were established using age stratification and validated by fitted multivariate linear regression modelling.Results Age was found to be an independent factor extensively associated with lipid levels in both sexes when adjusted for serum glucose, body mass index, lifestyle, drinking and smoking. Age was positively associated with TC, logarithm-transformed TG (LnTG) and LDL-C levels in men ≤40, ≤40 and ≤60 years old (yo) and in women ≤60, ≤70 and ≤60 yo, respectively. Conversely, age correlated negatively with TC, LnTG and LDL-C levels in men ≥61, ≥41 and ≥61 yo and in women ≥61, ≥71 and ≥61 yo, respectively. TC, TG and LDL-C levels in women were initially lower than those in men but surpassed those in men in 51–55, 61–65 and 51–55 yo age groups. The trends in HDL-C levels with age were relatively irregular, although HDL-C levels in women were higher than in men for all age groups.Conclusions The definition of dyslipidaemia, the atherosclerotic cardiovascular disease risk assessment and the initiation/goals of statin therapy should fully consider age-related trends in lipid levels and sex differences. |
| format | Article |
| id | doaj-art-451fc32c2e9641a3829bec6a51c496bb |
| institution | OA Journals |
| issn | 2044-6055 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-451fc32c2e9641a3829bec6a51c496bb2025-08-20T02:20:36ZengBMJ Publishing GroupBMJ Open2044-60552020-03-0110310.1136/bmjopen-2019-034226Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese populationYing Zhu0Ying Li1Xuan Luo2Shiyan Nian3Zongwu Tong4Chunting Zhang5Xuejing Bai6Mengna Wu7Zefeng Yan8Department of Laboratory, People’s Hospital of Yuxi City, Yuxi, ChinaAcupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, ChinaDepartment of Critical Care Medicine, People’s Hospital of Yuxi City, Yuxi, ChinaDepartment of Nephrology, People’s Hospital of Yuxi City, Yuxi, ChinaDepartment of Laboratory, People’s Hospital of Yuxi City, Yuxi, ChinaDepartment of Laboratory, Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, ChinaDepartment of Laboratory, Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, ChinaDepartment of Laboratory, Sixth Affiliated Hospital of Kunming Medical University, Yuxi, Yunnan, ChinaObjectives This study aimed to investigate the dynamic trends in total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) levels with ageing.Design A Chinese population-based cross-sectional study.Setting A physical examination centre of a general hospital.Participants Adult subjects (178 167: 103 461 men and 74 706 women) without a known medical history or treatments that affect lipid metabolism.Main outcome measures Dynamic trends in the above-mentioned lipid parameters with ageing were explored; turning points of age were established using age stratification and validated by fitted multivariate linear regression modelling.Results Age was found to be an independent factor extensively associated with lipid levels in both sexes when adjusted for serum glucose, body mass index, lifestyle, drinking and smoking. Age was positively associated with TC, logarithm-transformed TG (LnTG) and LDL-C levels in men ≤40, ≤40 and ≤60 years old (yo) and in women ≤60, ≤70 and ≤60 yo, respectively. Conversely, age correlated negatively with TC, LnTG and LDL-C levels in men ≥61, ≥41 and ≥61 yo and in women ≥61, ≥71 and ≥61 yo, respectively. TC, TG and LDL-C levels in women were initially lower than those in men but surpassed those in men in 51–55, 61–65 and 51–55 yo age groups. The trends in HDL-C levels with age were relatively irregular, although HDL-C levels in women were higher than in men for all age groups.Conclusions The definition of dyslipidaemia, the atherosclerotic cardiovascular disease risk assessment and the initiation/goals of statin therapy should fully consider age-related trends in lipid levels and sex differences.https://bmjopen.bmj.com/content/10/3/e034226.full |
| spellingShingle | Ying Zhu Ying Li Xuan Luo Shiyan Nian Zongwu Tong Chunting Zhang Xuejing Bai Mengna Wu Zefeng Yan Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population BMJ Open |
| title | Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population |
| title_full | Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population |
| title_fullStr | Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population |
| title_full_unstemmed | Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population |
| title_short | Age-related trends in lipid levels: a large-scale cross-sectional study of the general Chinese population |
| title_sort | age related trends in lipid levels a large scale cross sectional study of the general chinese population |
| url | https://bmjopen.bmj.com/content/10/3/e034226.full |
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