Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties
High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evalua...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2018/3698078 |
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| _version_ | 1850110653660921856 |
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| author | Vincenzo Giancotti Natascha Bergamin Palmina Cataldi Claudio Rizzi |
| author_facet | Vincenzo Giancotti Natascha Bergamin Palmina Cataldi Claudio Rizzi |
| author_sort | Vincenzo Giancotti |
| collection | DOAJ |
| description | High-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. HMGA proteins were coordinated or associated with histone and DNA modification and the expression of the factors related to pluripotency. CSCs showed remarkable differences compared with ESCs and iPSCs. |
| format | Article |
| id | doaj-art-451d0306208c408ebe75e0f48b7dd15d |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-451d0306208c408ebe75e0f48b7dd15d2025-08-20T02:37:47ZengWileyInternational Journal of Cell Biology1687-88761687-88842018-01-01201810.1155/2018/36980783698078Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell PropertiesVincenzo Giancotti0Natascha Bergamin1Palmina Cataldi2Claudio Rizzi3Department of Life Science, University of Trieste, Trieste, ItalyDivision of Pathology, Azienda Ospedaliero-Universitaria, Udine, ItalyDivision of Pathology, Azienda Ospedaliero-Universitaria, Udine, ItalyDivision of Pathology, Azienda Ospedaliero-Universitaria, Udine, ItalyHigh-mobility group A (HMGA) proteins have been examined to understand their participation as structural epigenetic chromatin factors that confer stem-like properties to embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and cancer stem cells (CSCs). The function of HMGA was evaluated in conjunction with that of other epigenetic factors such as histones and microRNAs (miRs), taking into consideration the posttranscriptional modifications (PTMs) of histones (acetylation and methylation) and DNA methylation. HMGA proteins were coordinated or associated with histone and DNA modification and the expression of the factors related to pluripotency. CSCs showed remarkable differences compared with ESCs and iPSCs.http://dx.doi.org/10.1155/2018/3698078 |
| spellingShingle | Vincenzo Giancotti Natascha Bergamin Palmina Cataldi Claudio Rizzi Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties International Journal of Cell Biology |
| title | Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties |
| title_full | Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties |
| title_fullStr | Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties |
| title_full_unstemmed | Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties |
| title_short | Epigenetic Contribution of High-Mobility Group A Proteins to Stem Cell Properties |
| title_sort | epigenetic contribution of high mobility group a proteins to stem cell properties |
| url | http://dx.doi.org/10.1155/2018/3698078 |
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