Double-blinded, randomized tolerance study of a biologically enhanced Nanogel with endothelin-1 and bradykinin receptor antagonist peptides via intra-articular injection for osteoarthritis treatment in horses

Double-blinded, randomized tolerance study of a biologically enhanced Nanogel with endothelin-1 and bradykinin receptor antagonist peptides via intra-articular injection for osteoarthritis treatment in horses

Abstract Background Osteoarthritis is a leading cause of pain and retirement in athletic horses. Hydro-expansive functionalized nanogels, acting as Drug Delivery Systems, constitute one of the current therapeutic prospects. These nanogels have the potential to combine mechanical benefits through pol...

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Main Authors: Antoinette Terlinden, Sandrine Jacquet, Seng Manivong, Aurélie Cullier, Frédéric Cassé, Florence Legendre, Araceli Ac Garcia, Gaëlle Roullin, Florina Moldovan, Pierre Sirois, Xavier Banquy, Philippe Galéra, Fabrice Audigié, Magali Demoor, Lélia Bertoni
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Veterinary Research
Subjects:
Horse
Osteoarthritis
Pain
Inflammation
Nanotechnology
Polymers
Online Access:https://doi.org/10.1186/s12917-024-04352-w
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