Precision oncology through next generation sequencing in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a primary liver cancer that originates from underlying inflammation, often associated with Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infections. Despite the availability of treatments, there are high rates of tumour relapse due to the development of drug re...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025004347 |
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| author | Sayali Shinde Carola Maria Bigogno Ana Simmons Nikita Kathuria Aruni Ghose Vedika Apte Patricia Lapitan Shania Makker Aydin Caglayan Stergios Boussios |
| author_facet | Sayali Shinde Carola Maria Bigogno Ana Simmons Nikita Kathuria Aruni Ghose Vedika Apte Patricia Lapitan Shania Makker Aydin Caglayan Stergios Boussios |
| author_sort | Sayali Shinde |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a primary liver cancer that originates from underlying inflammation, often associated with Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infections. Despite the availability of treatments, there are high rates of tumour relapse due to the development of drug resistance in infected cells. Next-Generation Sequencing (NGS) plays a crucial role in overcoming this issue by sequencing both viral and host genomes to identify mutations and genetic heterogeneity. The knowledge gained from sequencing is then utilised to develop countermeasures against these mutants through different combination therapies. Advances in NGS have led to sequencing with higher accuracy and throughput, thereby enabling personalized and effective treatments. The purpose of this article is to highlight how NGS has contributed to precision medicine in HCC and the possible integration of artificial intelligence (AI) to bolster the advancement. |
| format | Article |
| id | doaj-art-451c49c0b83242c2a309e9f7f4074ba9 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-451c49c0b83242c2a309e9f7f4074ba92025-01-25T04:11:23ZengElsevierHeliyon2405-84402025-02-01113e42054Precision oncology through next generation sequencing in hepatocellular carcinomaSayali Shinde0Carola Maria Bigogno1Ana Simmons2Nikita Kathuria3Aruni Ghose4Vedika Apte5Patricia Lapitan6Shania Makker7Aydin Caglayan8Stergios Boussios9Barts Cancer Institute, Queen Mary University of London, Cancer Research UK Barts Centre, London, UKDepartment of Medical Oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK; British Oncology Network for Undergraduate Societies (BONUS), UKFaculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; QIAGEN Manchester, Manchester, UKFaculty of Life Sciences and Medicine, King's College London, London, UKDepartment of Medical Oncology, St. Bartholomew's Hospital, Barts Health NHS Trust, London, UK; Department of Medical Oncology, Medway NHS Foundation Trust, Kent, UK; Department of Medical Oncology, Mount Vernon Cancer Centre, East and North Hertfordshire NHS Trust, London, UKUniversity College London Medical School, London, UK; University College London Oncology Society, London, UKSchool of Medical Sciences, The University of Manchester, Manchester, UK; Division of Genetics and Epidemiology, The Institute of Cancer Research, Surrey, UK; University College London Cancer Institute, London, UKUniversity College London Cancer Institute, London, UK; Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK; Barts and the London Oncology Society, London, UKDepartment of Medical Oncology, Medway NHS Foundation Trust, Kent, UKDepartment of Medical Oncology, Medway NHS Foundation Trust, Kent, UK; Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, Strand, London, UK; Kent and Medway Medical School, University of Kent, Canterbury, UK; Faculty of Medicine, Health, and Social Care, Canterbury Christ Church University, Canterbury, UK; AELIA Organization, 9th Km Thessaloniki–Thermi, 57001 Thessaloniki, Greece; Corresponding author. Faculty of Medicine, Health, and Social Care, Canterbury Christ Church University, Canterbury, UK; Faculty of Life Sciences & Medicine, School of Cancer & Pharmaceutical Sciences, King's College London, London, UK; Kent Medway Medical School, University of Kent, Canterbury, Kent, UK; Medway NHS Foundation Trust, Kent, Gillingham, UK.Hepatocellular carcinoma (HCC) is a primary liver cancer that originates from underlying inflammation, often associated with Hepatitis B virus (HBV) or Hepatitis C virus (HCV) infections. Despite the availability of treatments, there are high rates of tumour relapse due to the development of drug resistance in infected cells. Next-Generation Sequencing (NGS) plays a crucial role in overcoming this issue by sequencing both viral and host genomes to identify mutations and genetic heterogeneity. The knowledge gained from sequencing is then utilised to develop countermeasures against these mutants through different combination therapies. Advances in NGS have led to sequencing with higher accuracy and throughput, thereby enabling personalized and effective treatments. The purpose of this article is to highlight how NGS has contributed to precision medicine in HCC and the possible integration of artificial intelligence (AI) to bolster the advancement.http://www.sciencedirect.com/science/article/pii/S2405844025004347Hepatocellular carcinomaNext generation sequencingArtificial intelligencePrecision oncologyVirus |
| spellingShingle | Sayali Shinde Carola Maria Bigogno Ana Simmons Nikita Kathuria Aruni Ghose Vedika Apte Patricia Lapitan Shania Makker Aydin Caglayan Stergios Boussios Precision oncology through next generation sequencing in hepatocellular carcinoma Heliyon Hepatocellular carcinoma Next generation sequencing Artificial intelligence Precision oncology Virus |
| title | Precision oncology through next generation sequencing in hepatocellular carcinoma |
| title_full | Precision oncology through next generation sequencing in hepatocellular carcinoma |
| title_fullStr | Precision oncology through next generation sequencing in hepatocellular carcinoma |
| title_full_unstemmed | Precision oncology through next generation sequencing in hepatocellular carcinoma |
| title_short | Precision oncology through next generation sequencing in hepatocellular carcinoma |
| title_sort | precision oncology through next generation sequencing in hepatocellular carcinoma |
| topic | Hepatocellular carcinoma Next generation sequencing Artificial intelligence Precision oncology Virus |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025004347 |
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