Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss
Purpose Previous studies have reported the involvement of long noncoding RNAs (lncRNAs) in reproductive diseases via the regulation of target genes. This study aimed to determine whether lnc-prostate androgen-regulated transcript 1 (lnc-PART1)could be used as a biomarker of unexplained recurrent pre...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Gynecological Endocrinology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09513590.2024.2375582 |
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| author | Chen Lihua Su Hua Wang Wenzhan Jeson Standard Liang Denghui |
| author_facet | Chen Lihua Su Hua Wang Wenzhan Jeson Standard Liang Denghui |
| author_sort | Chen Lihua |
| collection | DOAJ |
| description | Purpose Previous studies have reported the involvement of long noncoding RNAs (lncRNAs) in reproductive diseases via the regulation of target genes. This study aimed to determine whether lnc-prostate androgen-regulated transcript 1 (lnc-PART1)could be used as a biomarker of unexplained recurrent pregnancy loss (URPL) and a possible predictor of poor pregnancy outcomes in women with URPL.Materials and methods Sixty patients with URPL and 15 healthy women were included in this study. PART1 expression was detected in plasma and endometrial tissues using a quantitative reverse transcription polymerase chain reaction. Logistic regression and receiver operating characteristic curve analyses were performed to analyze the association between PART1 expression and pregnancy outcomes in women with URPL.Results The expression of PART1transcript variant 2 was significantly up-regulated in the endometrial specimens from patients with URPL compared to control tissues. High tissue expression levels of PART1transcript variant 2 were associated with poor pregnancy outcomes in women with URPL, indicating that it could serve as a potential risk factor. Additionally, PART1 could serve as a potential risk factor for adverse pregnancy outcomes in patients with URPL (OR = 4.374; 95% CI = 1.052–18.189; p = .042).Conclusion lncRNA PART1 transcript variant 2 was highly expressed in patients with URPL. Therefore, it is important to conduct in-depth studies on the relationship between PART1 expression and URPL. |
| format | Article |
| id | doaj-art-451aed16a21a4cc490b62ce1c8ecc6ef |
| institution | OA Journals |
| issn | 0951-3590 1473-0766 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gynecological Endocrinology |
| spelling | doaj-art-451aed16a21a4cc490b62ce1c8ecc6ef2025-08-20T02:00:02ZengTaylor & Francis GroupGynecological Endocrinology0951-35901473-07662024-12-0140110.1080/09513590.2024.2375582Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy lossChen Lihua0Su Hua1Wang Wenzhan2Jeson Standard3Liang Denghui4Department of Reproductive Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, P.R. ChinaDepartment of Reproductive Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, P.R. ChinaDepartment of Reproductive Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, P.R. ChinaThe University of Hong Kong, Hong Kong IslandDepartment of Reproductive Medicine, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei, P.R. ChinaPurpose Previous studies have reported the involvement of long noncoding RNAs (lncRNAs) in reproductive diseases via the regulation of target genes. This study aimed to determine whether lnc-prostate androgen-regulated transcript 1 (lnc-PART1)could be used as a biomarker of unexplained recurrent pregnancy loss (URPL) and a possible predictor of poor pregnancy outcomes in women with URPL.Materials and methods Sixty patients with URPL and 15 healthy women were included in this study. PART1 expression was detected in plasma and endometrial tissues using a quantitative reverse transcription polymerase chain reaction. Logistic regression and receiver operating characteristic curve analyses were performed to analyze the association between PART1 expression and pregnancy outcomes in women with URPL.Results The expression of PART1transcript variant 2 was significantly up-regulated in the endometrial specimens from patients with URPL compared to control tissues. High tissue expression levels of PART1transcript variant 2 were associated with poor pregnancy outcomes in women with URPL, indicating that it could serve as a potential risk factor. Additionally, PART1 could serve as a potential risk factor for adverse pregnancy outcomes in patients with URPL (OR = 4.374; 95% CI = 1.052–18.189; p = .042).Conclusion lncRNA PART1 transcript variant 2 was highly expressed in patients with URPL. Therefore, it is important to conduct in-depth studies on the relationship between PART1 expression and URPL.https://www.tandfonline.com/doi/10.1080/09513590.2024.2375582Unexplained recurrent pregnancy lossPART1pregnancy outcomeandrogenlncRNA |
| spellingShingle | Chen Lihua Su Hua Wang Wenzhan Jeson Standard Liang Denghui Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss Gynecological Endocrinology Unexplained recurrent pregnancy loss PART1 pregnancy outcome androgen lncRNA |
| title | Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss |
| title_full | Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss |
| title_fullStr | Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss |
| title_full_unstemmed | Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss |
| title_short | Expression and clinical significance of lncRNA PART1 in patients with unexplained recurrent pregnancy loss |
| title_sort | expression and clinical significance of lncrna part1 in patients with unexplained recurrent pregnancy loss |
| topic | Unexplained recurrent pregnancy loss PART1 pregnancy outcome androgen lncRNA |
| url | https://www.tandfonline.com/doi/10.1080/09513590.2024.2375582 |
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