A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort.
<h4>Objective</h4>This pilot study aimed to inform future research evaluating the effectiveness of Platelet Rich Plasma (PRP) injection for tendinopathy.<h4>Design</h4>Randomized control trial (RCT) and synchronous observational cohort studies. For the RCT, consecutive consen...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0147842&type=printable |
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| author | Marni Wesner Terry Defreitas Heather Bredy Louisa Pothier Ziling Qin Ashley B McKillop Douglas P Gross |
| author_facet | Marni Wesner Terry Defreitas Heather Bredy Louisa Pothier Ziling Qin Ashley B McKillop Douglas P Gross |
| author_sort | Marni Wesner |
| collection | DOAJ |
| description | <h4>Objective</h4>This pilot study aimed to inform future research evaluating the effectiveness of Platelet Rich Plasma (PRP) injection for tendinopathy.<h4>Design</h4>Randomized control trial (RCT) and synchronous observational cohort studies. For the RCT, consecutive consenting patients treated at an academic sports medicine clinic were randomly assigned to either a PRP or placebo control group.<h4>Setting</h4>The Glen Sather Sport Medicine Clinic, Edmonton, Canada.<h4>Patients</h4>The RCT included 9 participants with rotator cuff tendinopathy. The cohort study included 178 participants with a variety of tendinopathies.<h4>Interventions</h4>Patients receiving PRP were injected with 4 ml of platelets into the supraspinatus and/or infraspinatus, while patients in the placebo group were injected with 4 ml of saline. All participants undertook a 3-month standardized, home-based, daily exercise program.<h4>Main outcome measures</h4>Participants in the RCT were re-evaluated 3, and 6 months post-injection. Change scores before and after injection on pain, disability and MRI-documented pathology outcomes were compared. In the cohort study, pain and disability were measured at 1, 2 and 3 months post-injection.<h4>Results</h4>For the RCT, 7 participants received PRP and 2 received placebo injections. Patients receiving PRP reported clinically important improvements in pain (>1.5/10 on VAS), disability (>15 point DASH change), and tendon pathology while those receiving placebo injections did not. In the observational cohort, statistically and clinically significant improvements in pain and disability were observed.<h4>Conclusion</h4>This pilot study provides information for planning future studies of PRP effectiveness. Preliminary results indicate intratendinous, ultrasound-guided PRP injection may lead to improvements in pain, function, and MRI-documented tendon pathology.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN68341698. |
| format | Article |
| id | doaj-art-451793e6bf35464d88d00d667d5b8cfd |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-451793e6bf35464d88d00d667d5b8cfd2025-08-20T03:53:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01112e014784210.1371/journal.pone.0147842A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort.Marni WesnerTerry DefreitasHeather BredyLouisa PothierZiling QinAshley B McKillopDouglas P Gross<h4>Objective</h4>This pilot study aimed to inform future research evaluating the effectiveness of Platelet Rich Plasma (PRP) injection for tendinopathy.<h4>Design</h4>Randomized control trial (RCT) and synchronous observational cohort studies. For the RCT, consecutive consenting patients treated at an academic sports medicine clinic were randomly assigned to either a PRP or placebo control group.<h4>Setting</h4>The Glen Sather Sport Medicine Clinic, Edmonton, Canada.<h4>Patients</h4>The RCT included 9 participants with rotator cuff tendinopathy. The cohort study included 178 participants with a variety of tendinopathies.<h4>Interventions</h4>Patients receiving PRP were injected with 4 ml of platelets into the supraspinatus and/or infraspinatus, while patients in the placebo group were injected with 4 ml of saline. All participants undertook a 3-month standardized, home-based, daily exercise program.<h4>Main outcome measures</h4>Participants in the RCT were re-evaluated 3, and 6 months post-injection. Change scores before and after injection on pain, disability and MRI-documented pathology outcomes were compared. In the cohort study, pain and disability were measured at 1, 2 and 3 months post-injection.<h4>Results</h4>For the RCT, 7 participants received PRP and 2 received placebo injections. Patients receiving PRP reported clinically important improvements in pain (>1.5/10 on VAS), disability (>15 point DASH change), and tendon pathology while those receiving placebo injections did not. In the observational cohort, statistically and clinically significant improvements in pain and disability were observed.<h4>Conclusion</h4>This pilot study provides information for planning future studies of PRP effectiveness. Preliminary results indicate intratendinous, ultrasound-guided PRP injection may lead to improvements in pain, function, and MRI-documented tendon pathology.<h4>Trial registration</h4>Controlled-Trials.com ISRCTN68341698.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0147842&type=printable |
| spellingShingle | Marni Wesner Terry Defreitas Heather Bredy Louisa Pothier Ziling Qin Ashley B McKillop Douglas P Gross A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. PLoS ONE |
| title | A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. |
| title_full | A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. |
| title_fullStr | A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. |
| title_full_unstemmed | A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. |
| title_short | A Pilot Study Evaluating the Effectiveness of Platelet-Rich Plasma Therapy for Treating Degenerative Tendinopathies: A Randomized Control Trial with Synchronous Observational Cohort. |
| title_sort | pilot study evaluating the effectiveness of platelet rich plasma therapy for treating degenerative tendinopathies a randomized control trial with synchronous observational cohort |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0147842&type=printable |
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