Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite
The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/4320175 |
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| _version_ | 1849405183605342208 |
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| author | Tommaso C. Bulfone Stephen P. Samuel Philip E. Bickler Matthew R. Lewin |
| author_facet | Tommaso C. Bulfone Stephen P. Samuel Philip E. Bickler Matthew R. Lewin |
| author_sort | Tommaso C. Bulfone |
| collection | DOAJ |
| description | The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge. Small molecule therapeutics (SMTs) have been proposed as potential prereferral treatments for snakebite to help address this gap. Herein, we discuss the characteristics, potential uses, and development of SMTs as potential treatments for snakebite envenomation. We focus on SMTs that are secretory phospholipase A2 (sPLA2) inhibitors with brief exploration of other potential drug targets on venom molecules. |
| format | Article |
| id | doaj-art-451091c4e43d4597abd79f4b20589d3c |
| institution | Kabale University |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-451091c4e43d4597abd79f4b20589d3c2025-08-20T03:36:44ZengWileyJournal of Tropical Medicine1687-96861687-96942018-01-01201810.1155/2018/43201754320175Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of SnakebiteTommaso C. Bulfone0Stephen P. Samuel1Philip E. Bickler2Matthew R. Lewin3California Academy of Sciences, San Francisco, 94118 CA, USACalifornia Academy of Sciences, San Francisco, 94118 CA, USAUniversity of California, San Francisco, 94118 CA, USACalifornia Academy of Sciences, San Francisco, 94118 CA, USAThe World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge. Small molecule therapeutics (SMTs) have been proposed as potential prereferral treatments for snakebite to help address this gap. Herein, we discuss the characteristics, potential uses, and development of SMTs as potential treatments for snakebite envenomation. We focus on SMTs that are secretory phospholipase A2 (sPLA2) inhibitors with brief exploration of other potential drug targets on venom molecules.http://dx.doi.org/10.1155/2018/4320175 |
| spellingShingle | Tommaso C. Bulfone Stephen P. Samuel Philip E. Bickler Matthew R. Lewin Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite Journal of Tropical Medicine |
| title | Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite |
| title_full | Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite |
| title_fullStr | Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite |
| title_full_unstemmed | Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite |
| title_short | Developing Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite |
| title_sort | developing small molecule therapeutics for the initial and adjunctive treatment of snakebite |
| url | http://dx.doi.org/10.1155/2018/4320175 |
| work_keys_str_mv | AT tommasocbulfone developingsmallmoleculetherapeuticsfortheinitialandadjunctivetreatmentofsnakebite AT stephenpsamuel developingsmallmoleculetherapeuticsfortheinitialandadjunctivetreatmentofsnakebite AT philipebickler developingsmallmoleculetherapeuticsfortheinitialandadjunctivetreatmentofsnakebite AT matthewrlewin developingsmallmoleculetherapeuticsfortheinitialandadjunctivetreatmentofsnakebite |