Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritis
The presented review searched for articles in the databases PubMed, Web of Science, Scopus, Google Scholar, eLibrary (2002-2022) and assessed the immunogenicity of the 23-valent polysaccharide pneumococcal vaccine (PPV23) in adult patients with rheumatoid arthritis (RA), receiving various antirheuma...
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| Format: | Article |
| Language: | Russian |
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Journal Infectology
2024-09-01
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| Series: | Журнал инфектологии |
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| Online Access: | https://journal.niidi.ru/jofin/article/view/1660 |
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| author | B. Ts. Batozhargalova N. A. Sagatbayeva G. M. Abdullayeva Sh. K. Bytyrkhanov I. L. Solovеva M. P. Kostinov A. D. Shmitko |
| author_facet | B. Ts. Batozhargalova N. A. Sagatbayeva G. M. Abdullayeva Sh. K. Bytyrkhanov I. L. Solovеva M. P. Kostinov A. D. Shmitko |
| author_sort | B. Ts. Batozhargalova |
| collection | DOAJ |
| description | The presented review searched for articles in the databases PubMed, Web of Science, Scopus, Google Scholar, eLibrary (2002-2022) and assessed the immunogenicity of the 23-valent polysaccharide pneumococcal vaccine (PPV23) in adult patients with rheumatoid arthritis (RA), receiving various antirheumatic drugs. The results of this review indicated sufficient immunogenicity of PPV23 in RA patients receiving monotherapy with various biological drugs (bDMARDs) (TNFα inhibitors, IL6 receptor inhibitors, T-lymphocyte costimulation blockers), targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs), and glucocorticoids (GC) in medium and low doses. Monotherapy with methotrexate (MTX), rituximab and combination therapy with bDMARDs +MTX, tsDMARDs+MTX in RA patients reduced the postvaccination pneumococcal response. IgG AT generated in response to PPV23 injection shown functional activity even in RA patients whose antibodies were either lowered in patients receiving MTX or were not detectable at protective values following bDMARD therapy. The potential for pneumococcus antibody production in RA patients receiving therapy with disease-modifying antirheumatic drugs (DMARDs), tsDMARDs and bDMARDs, was concluded. Vaccination against pneumococcal infection should be advised prior to starting therapy due to the likelihood of low antibody levels developing during rituximab treatment. |
| format | Article |
| id | doaj-art-4503875ccf024d85884d388111b7a372 |
| institution | Kabale University |
| issn | 2072-6732 |
| language | Russian |
| publishDate | 2024-09-01 |
| publisher | Journal Infectology |
| record_format | Article |
| series | Журнал инфектологии |
| spelling | doaj-art-4503875ccf024d85884d388111b7a3722025-08-20T04:00:18ZrusJournal InfectologyЖурнал инфектологии2072-67322024-09-01163364410.22625/2072-6732-2024-16-3-36-441160Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritisB. Ts. Batozhargalova0N. A. Sagatbayeva1G. M. Abdullayeva2Sh. K. Bytyrkhanov3I. L. Solovеva4M. P. Kostinov5A. D. Shmitko6Research Institute of Vaccines and Sera named after I.I. MechnikovKazakh National Medical University named after S.D. AsfendivarovKazakh National Medical University named after S.D. AsfendivarovKazakh National Medical University named after S.D. AsfendivarovUlyanovsk State UniversityResearch Institute of Vaccines and Sera named after I.I. Mechnikov; First Moscow State Medical University named after I.M. Sechenov (Sechenov University)Research Institute of Vaccines and Sera named after I.I. MechnikovThe presented review searched for articles in the databases PubMed, Web of Science, Scopus, Google Scholar, eLibrary (2002-2022) and assessed the immunogenicity of the 23-valent polysaccharide pneumococcal vaccine (PPV23) in adult patients with rheumatoid arthritis (RA), receiving various antirheumatic drugs. The results of this review indicated sufficient immunogenicity of PPV23 in RA patients receiving monotherapy with various biological drugs (bDMARDs) (TNFα inhibitors, IL6 receptor inhibitors, T-lymphocyte costimulation blockers), targeted synthetic disease-modifying antirheumatic drugs (tsDMARDs), and glucocorticoids (GC) in medium and low doses. Monotherapy with methotrexate (MTX), rituximab and combination therapy with bDMARDs +MTX, tsDMARDs+MTX in RA patients reduced the postvaccination pneumococcal response. IgG AT generated in response to PPV23 injection shown functional activity even in RA patients whose antibodies were either lowered in patients receiving MTX or were not detectable at protective values following bDMARD therapy. The potential for pneumococcus antibody production in RA patients receiving therapy with disease-modifying antirheumatic drugs (DMARDs), tsDMARDs and bDMARDs, was concluded. Vaccination against pneumococcal infection should be advised prior to starting therapy due to the likelihood of low antibody levels developing during rituximab treatment.https://journal.niidi.ru/jofin/article/view/1660immunogenicity23-valent polysaccharide pneumococcal vaccinerheumatoid arthritistherapy |
| spellingShingle | B. Ts. Batozhargalova N. A. Sagatbayeva G. M. Abdullayeva Sh. K. Bytyrkhanov I. L. Solovеva M. P. Kostinov A. D. Shmitko Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritis Журнал инфектологии immunogenicity 23-valent polysaccharide pneumococcal vaccine rheumatoid arthritis therapy |
| title | Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritis |
| title_full | Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritis |
| title_fullStr | Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritis |
| title_full_unstemmed | Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritis |
| title_short | Immunogenicity of Pneumococcal Polysaccharide Vaccine in patients with rheumatoid arthritis |
| title_sort | immunogenicity of pneumococcal polysaccharide vaccine in patients with rheumatoid arthritis |
| topic | immunogenicity 23-valent polysaccharide pneumococcal vaccine rheumatoid arthritis therapy |
| url | https://journal.niidi.ru/jofin/article/view/1660 |
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