Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly
Aim. To determine the incidence of interstitial myocardial fibrosis (MF) in acromegaly, which leads to the development of cardiac arrhythmias and conduction disorders. Materials and methods. A single-center study was conducted, including 70 patients with acromegaly. All patients underwent standar...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2024-12-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/633116/pdf |
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| author | Alina A. Almaskhanova Konstantin V. Melkozerov Elena G. Przhiyalkovskaya Natalia V. Tarbaeva Anastasya Y. Korneluk Raisa S. Kosharnaia Victor Y. Kalashnikov Zhanna E. Belaya Galina A. Mel'nichenko Natalia G. Mokrysheva |
| author_facet | Alina A. Almaskhanova Konstantin V. Melkozerov Elena G. Przhiyalkovskaya Natalia V. Tarbaeva Anastasya Y. Korneluk Raisa S. Kosharnaia Victor Y. Kalashnikov Zhanna E. Belaya Galina A. Mel'nichenko Natalia G. Mokrysheva |
| author_sort | Alina A. Almaskhanova |
| collection | DOAJ |
| description | Aim. To determine the incidence of interstitial myocardial fibrosis (MF) in acromegaly, which leads to the development of cardiac arrhythmias and conduction disorders.
Materials and methods. A single-center study was conducted, including 70 patients with acromegaly. All patients underwent standard medical examinations, including hormonal blood tests, electrocardiograms, echocardiography, Holter monitoring electrocardiograms and magnetic resonance imaging (MRI) of the heart with gadolinium contrast, additionally 48 patients underwent T1-mapping, which is an MRI method that allows the detection of diffuse changes by measuring the values of myocardial relaxation time – T1.
Results. The study revealed a high incidence of MF – 53 (75.7%) cases (21 women, 32 men). The duration of the disease was found to be critical for myocardial remodeling (p=0.006). Compliance criteria for the T1-mapping technique were determined, with reduced T1-mapping values observed in 85.2% of cases. The ROC analysis (Receiver Operator Characteristic) determined the diagnostic value of post-contrast T1-mapping: AUC (Area Under the Curve)=0.906 (95% confidence interval 0.789–1.000), a sensitivity of 90%, and a specificity of 76.5%, indicating high diagnostic efficiency. According to the Youden index, a cut-off point of 372.5 ms was selected.
Conclusion. Myocardial T1-mapping is a novel MRI method that allows to assess the degree of MF without the need for myocardial biopsy. The obtained information is crucial for the diagnosis and prognostic assessment of heart diseases, particularly in cases of hypertrophic cardiomyopathy or infiltrative diseases. The T1-mapping method, which is actively developing, can serve as a marker for early diffuse myocardial fibrosis and help determine the prognosis for patients with acromegalic cardiomyopathy. |
| format | Article |
| id | doaj-art-45014a7e780941af9c62651eff5cd564 |
| institution | Kabale University |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| publishDate | 2024-12-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj-art-45014a7e780941af9c62651eff5cd5642025-01-21T11:09:17Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422024-12-01961095095610.26442/00403660.2024.10.20287178564Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegalyAlina A. Almaskhanova0https://orcid.org/0000-0002-2320-2532Konstantin V. Melkozerov1https://orcid.org/0000-0002-7328-6316Elena G. Przhiyalkovskaya2https://orcid.org/0000-0001-9119-2447Natalia V. Tarbaeva3https://orcid.org/0000-0001-7965-9454Anastasya Y. Korneluk4https://orcid.org/0009-0007-4475-8752Raisa S. Kosharnaia5https://orcid.org/0000-0003-1387-683XVictor Y. Kalashnikov6https://orcid.org/0000-0001-5573-0754Zhanna E. Belaya7https://orcid.org/0000-0002-6674-6441Galina A. Mel'nichenko8https://orcid.org/0000-0002-5634-7877Natalia G. Mokrysheva9https://orcid.org/0000-0003-2604-8347Endocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreEndocrinology Research CentreAim. To determine the incidence of interstitial myocardial fibrosis (MF) in acromegaly, which leads to the development of cardiac arrhythmias and conduction disorders. Materials and methods. A single-center study was conducted, including 70 patients with acromegaly. All patients underwent standard medical examinations, including hormonal blood tests, electrocardiograms, echocardiography, Holter monitoring electrocardiograms and magnetic resonance imaging (MRI) of the heart with gadolinium contrast, additionally 48 patients underwent T1-mapping, which is an MRI method that allows the detection of diffuse changes by measuring the values of myocardial relaxation time – T1. Results. The study revealed a high incidence of MF – 53 (75.7%) cases (21 women, 32 men). The duration of the disease was found to be critical for myocardial remodeling (p=0.006). Compliance criteria for the T1-mapping technique were determined, with reduced T1-mapping values observed in 85.2% of cases. The ROC analysis (Receiver Operator Characteristic) determined the diagnostic value of post-contrast T1-mapping: AUC (Area Under the Curve)=0.906 (95% confidence interval 0.789–1.000), a sensitivity of 90%, and a specificity of 76.5%, indicating high diagnostic efficiency. According to the Youden index, a cut-off point of 372.5 ms was selected. Conclusion. Myocardial T1-mapping is a novel MRI method that allows to assess the degree of MF without the need for myocardial biopsy. The obtained information is crucial for the diagnosis and prognostic assessment of heart diseases, particularly in cases of hypertrophic cardiomyopathy or infiltrative diseases. The T1-mapping method, which is actively developing, can serve as a marker for early diffuse myocardial fibrosis and help determine the prognosis for patients with acromegalic cardiomyopathy.https://ter-arkhiv.ru/0040-3660/article/viewFile/633116/pdfacromegalyheart arrhythmia and conduction disordercardiac magnetic resonance imagingacromegalic cardiomyopathymyocardial fibrosismyocardial hypertrophy |
| spellingShingle | Alina A. Almaskhanova Konstantin V. Melkozerov Elena G. Przhiyalkovskaya Natalia V. Tarbaeva Anastasya Y. Korneluk Raisa S. Kosharnaia Victor Y. Kalashnikov Zhanna E. Belaya Galina A. Mel'nichenko Natalia G. Mokrysheva Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly Терапевтический архив acromegaly heart arrhythmia and conduction disorder cardiac magnetic resonance imaging acromegalic cardiomyopathy myocardial fibrosis myocardial hypertrophy |
| title | Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly |
| title_full | Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly |
| title_fullStr | Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly |
| title_full_unstemmed | Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly |
| title_short | Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly |
| title_sort | advantages of using t1 mapping in cardiac magnetic resonance imaging in patients with acromegaly |
| topic | acromegaly heart arrhythmia and conduction disorder cardiac magnetic resonance imaging acromegalic cardiomyopathy myocardial fibrosis myocardial hypertrophy |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/633116/pdf |
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