Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event
Involvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia/small lymphocytic lymphoma and an embolic cerebro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/1825491 |
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| _version_ | 1850110710577627136 |
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| author | Nicolas Gallastegui Daniel P. Cassidy Deborah O. Heros Francisco Vega Jonathan H. Schatz |
| author_facet | Nicolas Gallastegui Daniel P. Cassidy Deborah O. Heros Francisco Vega Jonathan H. Schatz |
| author_sort | Nicolas Gallastegui |
| collection | DOAJ |
| description | Involvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia/small lymphocytic lymphoma and an embolic cerebrovascular accident related to a cardiac myxoma, who developed parenchymal central nervous system involvement of lymphoma on the ischemic bed. The patient was successfully treated with a high-dose fludarabine-based chemotherapy regimen, achieving a sustained remission. We propose that embolic breakage of the blood-brain barrier may be a major risk factor in producing central nervous system involvement. We also propose that a high-dose fludarabine-based chemotherapy regimen may be adequate to achieve a better CNS penetration and improved outcomes. |
| format | Article |
| id | doaj-art-450048b384344b2d91f3aa6c7fc36b5d |
| institution | OA Journals |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-450048b384344b2d91f3aa6c7fc36b5d2025-08-20T02:37:47ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/18254911825491Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic EventNicolas Gallastegui0Daniel P. Cassidy1Deborah O. Heros2Francisco Vega3Jonathan H. Schatz4Division of Hematology, Department of Medicine, University of Miami Leonard M. Miller School of Medicine/Sylvester Comprehensive Cancer Center, Miami, FL, USADivision of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami Leonard M. Miller School of Medicine/Sylvester Comprehensive Cancer Center, Miami, FL, USADivision of Neuro-Oncology, Department of Neurology, University of Miami Leonard M. Miller School of Medicine/Sylvester Comprehensive Cancer Center, Miami, FL, USADivision of Hematopathology, Department of Pathology and Laboratory Medicine, University of Miami Leonard M. Miller School of Medicine/Sylvester Comprehensive Cancer Center, Miami, FL, USADivision of Hematology, Department of Medicine, University of Miami Leonard M. Miller School of Medicine/Sylvester Comprehensive Cancer Center, Miami, FL, USAInvolvement of the central nervous system by chronic lymphocytic leukemia/small lymphocytic lymphoma is exceedingly rare, and currently no risk factors have been described. We report the case of a patient with concomitant chronic lymphocytic leukemia/small lymphocytic lymphoma and an embolic cerebrovascular accident related to a cardiac myxoma, who developed parenchymal central nervous system involvement of lymphoma on the ischemic bed. The patient was successfully treated with a high-dose fludarabine-based chemotherapy regimen, achieving a sustained remission. We propose that embolic breakage of the blood-brain barrier may be a major risk factor in producing central nervous system involvement. We also propose that a high-dose fludarabine-based chemotherapy regimen may be adequate to achieve a better CNS penetration and improved outcomes.http://dx.doi.org/10.1155/2019/1825491 |
| spellingShingle | Nicolas Gallastegui Daniel P. Cassidy Deborah O. Heros Francisco Vega Jonathan H. Schatz Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event Case Reports in Hematology |
| title | Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event |
| title_full | Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event |
| title_fullStr | Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event |
| title_full_unstemmed | Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event |
| title_short | Central Nervous System Involvement by Small Lymphocytic Lymphoma after a Myxoma-Related Embolic Event |
| title_sort | central nervous system involvement by small lymphocytic lymphoma after a myxoma related embolic event |
| url | http://dx.doi.org/10.1155/2019/1825491 |
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