Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation
BackgroundElectrical remodeling has been linked to the progression and recurrence of atrial fibrillation (AF) after catheter ablation (CA). Substrate mapping based solely on a voltage amplitude electrogram (EGM) does not provide a comprehensive understanding of the left atrial (LA) disease. The aim...
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2024.1474568/full |
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| author | Lorenzo Gigli Lorenzo Gigli Alberto Preda Davide Coluzzi Marta Sartore Muhamed Vila Marco Carbonaro Matteo Baroni Marisa Varrenti Sara Vargiu Fabrizio Guarracini Antonio Frontera Luigi Pannone Gian Battista Chierchia Carlo De Asmundis Patrizio Mazzone Roberto Sassi |
| author_facet | Lorenzo Gigli Lorenzo Gigli Alberto Preda Davide Coluzzi Marta Sartore Muhamed Vila Marco Carbonaro Matteo Baroni Marisa Varrenti Sara Vargiu Fabrizio Guarracini Antonio Frontera Luigi Pannone Gian Battista Chierchia Carlo De Asmundis Patrizio Mazzone Roberto Sassi |
| author_sort | Lorenzo Gigli |
| collection | DOAJ |
| description | BackgroundElectrical remodeling has been linked to the progression and recurrence of atrial fibrillation (AF) after catheter ablation (CA). Substrate mapping based solely on a voltage amplitude electrogram (EGM) does not provide a comprehensive understanding of the left atrial (LA) disease. The aim of this study is to assess left atrial spatial entropy (LASE) from voltage maps routinely obtained during AF ablation to further characterize the LA substrate.Materials and MethodsHigh-density electroanatomic maps (EAMs) of 27 patients with paroxysmal or persistent AF undergoing routine CA were prospectively collected. Computational post-processing was performed on the voltage maps. Using the Shannon entropy model, the probability distribution of the amplitude range values associated with each point of the map was used to measure LASE. Finally, correlations between LASE and clinical and electrophysiological characteristics of AF were explored.ResultsLASE differentiated between patients with paroxysmal and persistent AF (6.45 ± 0.41 vs. 5.87 ± 0.53; p = 0.028) and patients with normal and abnormal LA substrate (6.42 ± 0.42 vs. 5.87 ± 0.56; p = 0.043), independent of the basal rhythm during EM acquisition (6.33 ± 0.41 vs. 6.11 ± 0.63; p = 0.619). Accordance between LASE and EAMs was assessed by ROC analysis (AUC: 0.81; C.I.: 0.62–0.99; Youden index: 6.06; sensitivity: 80%; and specificity: 80%). Patients with the lowest LASE reported AF recurrence at the follow-up.ConclusionLASE may play a role in the further characterization of the LA substrate and the type of AF, independent of basal rhythm. |
| format | Article |
| id | doaj-art-44f8d64c0d704504abbe605a16f19ae5 |
| institution | OA Journals |
| issn | 1664-042X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj-art-44f8d64c0d704504abbe605a16f19ae52025-08-20T02:27:42ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2024-11-011510.3389/fphys.2024.14745681474568Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillationLorenzo Gigli0Lorenzo Gigli1Alberto Preda2Davide Coluzzi3Marta Sartore4Muhamed Vila5Marco Carbonaro6Matteo Baroni7Marisa Varrenti8Sara Vargiu9Fabrizio Guarracini10Antonio Frontera11Luigi Pannone12Gian Battista Chierchia13Carlo De Asmundis14Patrizio Mazzone15Roberto Sassi16De Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel – Vrije Universiteit Brussel, Brussels, BelgiumDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDepartment of Computer Science, University of Milan, Milan, ItalyDepartment of Computer Science, University of Milan, Milan, ItalyDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel – Vrije Universiteit Brussel, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel – Vrije Universiteit Brussel, Brussels, BelgiumHeart Rhythm Management Centre, Postgraduate Program in Cardiac Electrophysiology and Pacing, Universitair Ziekenhuis Brussel – Vrije Universiteit Brussel, Brussels, BelgiumDe Gasperis Cardio Center, Electrophysiology Unit, Niguarda Hospital, Milan, ItalyDepartment of Computer Science, University of Milan, Milan, ItalyBackgroundElectrical remodeling has been linked to the progression and recurrence of atrial fibrillation (AF) after catheter ablation (CA). Substrate mapping based solely on a voltage amplitude electrogram (EGM) does not provide a comprehensive understanding of the left atrial (LA) disease. The aim of this study is to assess left atrial spatial entropy (LASE) from voltage maps routinely obtained during AF ablation to further characterize the LA substrate.Materials and MethodsHigh-density electroanatomic maps (EAMs) of 27 patients with paroxysmal or persistent AF undergoing routine CA were prospectively collected. Computational post-processing was performed on the voltage maps. Using the Shannon entropy model, the probability distribution of the amplitude range values associated with each point of the map was used to measure LASE. Finally, correlations between LASE and clinical and electrophysiological characteristics of AF were explored.ResultsLASE differentiated between patients with paroxysmal and persistent AF (6.45 ± 0.41 vs. 5.87 ± 0.53; p = 0.028) and patients with normal and abnormal LA substrate (6.42 ± 0.42 vs. 5.87 ± 0.56; p = 0.043), independent of the basal rhythm during EM acquisition (6.33 ± 0.41 vs. 6.11 ± 0.63; p = 0.619). Accordance between LASE and EAMs was assessed by ROC analysis (AUC: 0.81; C.I.: 0.62–0.99; Youden index: 6.06; sensitivity: 80%; and specificity: 80%). Patients with the lowest LASE reported AF recurrence at the follow-up.ConclusionLASE may play a role in the further characterization of the LA substrate and the type of AF, independent of basal rhythm.https://www.frontiersin.org/articles/10.3389/fphys.2024.1474568/fullatrial fibrillationleft atrial spatial entropycatheter ablationsubstrate characterizationmapping technologies |
| spellingShingle | Lorenzo Gigli Lorenzo Gigli Alberto Preda Davide Coluzzi Marta Sartore Muhamed Vila Marco Carbonaro Matteo Baroni Marisa Varrenti Sara Vargiu Fabrizio Guarracini Antonio Frontera Luigi Pannone Gian Battista Chierchia Carlo De Asmundis Patrizio Mazzone Roberto Sassi Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation Frontiers in Physiology atrial fibrillation left atrial spatial entropy catheter ablation substrate characterization mapping technologies |
| title | Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation |
| title_full | Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation |
| title_fullStr | Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation |
| title_full_unstemmed | Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation |
| title_short | Left atrial spatial entropy: a novel tool for electrophysiological substrate characterization in atrial fibrillation |
| title_sort | left atrial spatial entropy a novel tool for electrophysiological substrate characterization in atrial fibrillation |
| topic | atrial fibrillation left atrial spatial entropy catheter ablation substrate characterization mapping technologies |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2024.1474568/full |
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