Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications
Introduction Antidepressants such as amitriptyline, bupropion and agomelatine are widely used not only in the treatment of depression, but also in other conditions. Their mechanisms of action affect different neurotransmitter systems, allowing their use in the treatment of pain, addiction or sle...
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Nicolaus Copernicus University in Toruń
2025-03-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/58924 |
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| author | Piotr Czerniak Julia Buszek Michał Medygrał Przemysław Koszuta Małgorzata Dydoń-Pikor Katarzyna Pajdak-Gicala Maciej Kawecki Adrianna Antoszewska Weronika Bargiel Sylwia Buszek |
| author_facet | Piotr Czerniak Julia Buszek Michał Medygrał Przemysław Koszuta Małgorzata Dydoń-Pikor Katarzyna Pajdak-Gicala Maciej Kawecki Adrianna Antoszewska Weronika Bargiel Sylwia Buszek |
| author_sort | Piotr Czerniak |
| collection | DOAJ |
| description |
Introduction
Antidepressants such as amitriptyline, bupropion and agomelatine are widely used not only in the treatment of depression, but also in other conditions. Their mechanisms of action affect different neurotransmitter systems, allowing their use in the treatment of pain, addiction or sleep disorders. Amitriptyline, which is a tricyclic antidepressant, has strong analgesic effects. Bupropion, a dopamine and norepinephrine reuptake inhibitor, helps in the treatment of addiction and ADHD. Agomelatine, a melatonin receptor agonist, has been shown to regulate diurnal rhythms, making it useful in the treatment of insomnia and other sleep disorders.
Aim of the Study
The aim of this study is to analyse the use of amitriptyline, bupropion and agomelatine in the treatment of conditions other than depression, with a focus on their mechanisms of action and clinical efficacy.
Materials and Methods
An analysis of PubMed papers was conducted using keywords: antidepressants, tricyclic antidepressants, SSRI, amitriptyline, bupropion, agomelatine.
Basic Results
Amitriptyline is highly effective in the treatment of neuropathic pain, migraines and insomnia due to its potent action on serotonin and histamine receptors. Bupropion is used in the treatment of nicotine addiction and ADHD, as it acts on the dopaminergic and noradrenergic systems to improve concentration and impulse control. Agomelatine, as a melatonin receptor agonist, is used to regulate diurnal rhythms, making it helpful in the treatment of sleep disorders and adaptation to time zone changes. Each of these drugs has unique properties that go beyond their primary use in depression.
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| format | Article |
| id | doaj-art-44f211ca44bd40ac99835fbfe57a48d0 |
| institution | DOAJ |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-44f211ca44bd40ac99835fbfe57a48d02025-08-20T02:59:52ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-03-013910.12775/QS.2025.39.58924Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indicationsPiotr Czerniak0https://orcid.org/0009-0007-3582-4586Julia Buszek1https://orcid.org/0009-0001-3832-2668Michał Medygrał2https://orcid.org/0009-0000-8723-2186Przemysław Koszuta3https://orcid.org/0009-0001-0988-4813Małgorzata Dydoń-Pikor4https://orcid.org/0009-0009-1976-1516Katarzyna Pajdak-Gicala5https://orcid.org/0009-0007-3234-8115Maciej Kawecki6https://orcid.org/0009-0000-0708-5316Adrianna Antoszewska7https://orcid.org/0009-0009-4518-1726Weronika Bargiel8https://orcid.org/0009-0008-5907-8159Sylwia Buszek9https://orcid.org/0009-0007-7214-7991Uniwersytet RzeszowskiUniwersytet RzeszowskiUniwersytet RzeszowskiArtdentis, Zapiecek 16, 97-200 Tomaszow Mazowiecki, PolandMedical University of Silesia, ul. Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Silesia, ul. Poniatowskiego 15, 40-055 Katowice, PolandMedical University of Warsaw, ul. Zwirki i Wigury 61, 02-091 Warsaw, PolandUniwersytet RzeszowskiUniwersytet RzeszowskiFrederic Chopin University Clinical Hospital in Rzeszow Fryderyka Szopena 2, 35-055 Rzeszow, Poland Introduction Antidepressants such as amitriptyline, bupropion and agomelatine are widely used not only in the treatment of depression, but also in other conditions. Their mechanisms of action affect different neurotransmitter systems, allowing their use in the treatment of pain, addiction or sleep disorders. Amitriptyline, which is a tricyclic antidepressant, has strong analgesic effects. Bupropion, a dopamine and norepinephrine reuptake inhibitor, helps in the treatment of addiction and ADHD. Agomelatine, a melatonin receptor agonist, has been shown to regulate diurnal rhythms, making it useful in the treatment of insomnia and other sleep disorders. Aim of the Study The aim of this study is to analyse the use of amitriptyline, bupropion and agomelatine in the treatment of conditions other than depression, with a focus on their mechanisms of action and clinical efficacy. Materials and Methods An analysis of PubMed papers was conducted using keywords: antidepressants, tricyclic antidepressants, SSRI, amitriptyline, bupropion, agomelatine. Basic Results Amitriptyline is highly effective in the treatment of neuropathic pain, migraines and insomnia due to its potent action on serotonin and histamine receptors. Bupropion is used in the treatment of nicotine addiction and ADHD, as it acts on the dopaminergic and noradrenergic systems to improve concentration and impulse control. Agomelatine, as a melatonin receptor agonist, is used to regulate diurnal rhythms, making it helpful in the treatment of sleep disorders and adaptation to time zone changes. Each of these drugs has unique properties that go beyond their primary use in depression. https://apcz.umk.pl/QS/article/view/58924antidepressantstricyclic antidepressantsSSRIamitriptylinebupropionagomelatine |
| spellingShingle | Piotr Czerniak Julia Buszek Michał Medygrał Przemysław Koszuta Małgorzata Dydoń-Pikor Katarzyna Pajdak-Gicala Maciej Kawecki Adrianna Antoszewska Weronika Bargiel Sylwia Buszek Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications Quality in Sport antidepressants tricyclic antidepressants SSRI amitriptyline bupropion agomelatine |
| title | Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications |
| title_full | Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications |
| title_fullStr | Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications |
| title_full_unstemmed | Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications |
| title_short | Use of amitriptyline, bupropion and agomelatine in the treatment of non-depressive disorders: a review of mechanisms and therapeutic indications |
| title_sort | use of amitriptyline bupropion and agomelatine in the treatment of non depressive disorders a review of mechanisms and therapeutic indications |
| topic | antidepressants tricyclic antidepressants SSRI amitriptyline bupropion agomelatine |
| url | https://apcz.umk.pl/QS/article/view/58924 |
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