Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana
The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the effectiveness of the SP given to the preg...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Parasitology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/9231946 |
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| author | Danny F. Yeboah Richmond Afoakwah Ekene K. Nwaefuna Orish Verner Johnson N. Boampong |
| author_facet | Danny F. Yeboah Richmond Afoakwah Ekene K. Nwaefuna Orish Verner Johnson N. Boampong |
| author_sort | Danny F. Yeboah |
| collection | DOAJ |
| description | The use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the effectiveness of the SP given to the pregnant women in some selected health facilities in the Central Region of Ghana to prevent maternal malaria in pregnant women. A total of 543 pregnant women recruited from 7 selected health centres in Central Region of Ghana participated in the study. Parasite density of Plasmodium falciparum was determined from peripheral blood of the pregnant women using microscopy. High performance liquid chromatography (HPLC) and dissolution tester were used to determine the quality of the SP. Malaria infection was recorded in 11.2% of pregnant women who had a history of SP consumption. SP failed the dissolution test. Pregnant women who did not receive IPT-SP were 44%. Low haemoglobin level was recorded in 73.5% of the pregnant women. The results indicated that SP was substandard. IPT-SP is ineffective in preventing malaria infection. |
| format | Article |
| id | doaj-art-44ed1f2825c842e88a835a24126f190b |
| institution | Kabale University |
| issn | 2090-0023 2090-0031 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Parasitology Research |
| spelling | doaj-art-44ed1f2825c842e88a835a24126f190b2025-08-20T03:36:45ZengWileyJournal of Parasitology Research2090-00232090-00312016-01-01201610.1155/2016/92319469231946Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of GhanaDanny F. Yeboah0Richmond Afoakwah1Ekene K. Nwaefuna2Orish Verner3Johnson N. Boampong4Department of Biomedical and Forensic Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, GhanaDepartment of Biomedical and Forensic Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, GhanaBiotechnology and Nuclear Agriculture Research Institute, Ghana Atomic Energy Commission, Accra, GhanaDepartment of Microbiology and Immunology, School of Medicine, University of Health and Allied Sciences, Ho, GhanaDepartment of Biomedical and Forensic Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, GhanaThe use of sulfadoxine-pyrimethamine (SP) as an intermittent preventive treatment (IPT) against malaria during pregnancy has become a policy in most sub-Sahara African countries and crucially depends on the efficacy of SP. This study sets out to evaluate the effectiveness of the SP given to the pregnant women in some selected health facilities in the Central Region of Ghana to prevent maternal malaria in pregnant women. A total of 543 pregnant women recruited from 7 selected health centres in Central Region of Ghana participated in the study. Parasite density of Plasmodium falciparum was determined from peripheral blood of the pregnant women using microscopy. High performance liquid chromatography (HPLC) and dissolution tester were used to determine the quality of the SP. Malaria infection was recorded in 11.2% of pregnant women who had a history of SP consumption. SP failed the dissolution test. Pregnant women who did not receive IPT-SP were 44%. Low haemoglobin level was recorded in 73.5% of the pregnant women. The results indicated that SP was substandard. IPT-SP is ineffective in preventing malaria infection.http://dx.doi.org/10.1155/2016/9231946 |
| spellingShingle | Danny F. Yeboah Richmond Afoakwah Ekene K. Nwaefuna Orish Verner Johnson N. Boampong Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana Journal of Parasitology Research |
| title | Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana |
| title_full | Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana |
| title_fullStr | Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana |
| title_full_unstemmed | Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana |
| title_short | Quality of Sulfadoxine-Pyrimethamine Given as Antimalarial Prophylaxis in Pregnant Women in Selected Health Facilities in Central Region of Ghana |
| title_sort | quality of sulfadoxine pyrimethamine given as antimalarial prophylaxis in pregnant women in selected health facilities in central region of ghana |
| url | http://dx.doi.org/10.1155/2016/9231946 |
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