BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE
Aim: Тo study the bone turnover markers (BTMs) in male patients with coronary artery disease (CAD). Materials and Methods: We recruited 102 male patients with CAD (mean age 60.8±6.9 years) and performed coronary angiography along with a multislice computed tomography f...
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| Format: | Article |
| Language: | Russian |
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Kemerovo State Medical University
2016-03-01
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| Series: | Фундаментальная и клиническая медицина |
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| Online Access: | https://fcm.kemsmu.ru/jour/article/view/6 |
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| author | Anna V. Voronkina Tatiana A. Raskina Elena B. Malyuta Marina V. Letaeva Oksana N. Hryachkova Alexandr N. Kokov Olga L. Barbarash |
| author_facet | Anna V. Voronkina Tatiana A. Raskina Elena B. Malyuta Marina V. Letaeva Oksana N. Hryachkova Alexandr N. Kokov Olga L. Barbarash |
| author_sort | Anna V. Voronkina |
| collection | DOAJ |
| description | Aim: Тo study the bone turnover markers (BTMs) in male patients with coronary artery disease (CAD). Materials and Methods: We recruited 102 male patients with CAD (mean age 60.8±6.9 years) and performed coronary angiography along with a multislice computed tomography following the measurement of BTMs (osteocalcin, bone alkaline phosphatase (BAP), and cathepsin K). Coronary artery calcification was evaluated by Agatston score. Results: We found a significant increase in serum levels of BAP and cathepsin K in patients with CAD compared to the healthy controls, indicating a high rate of bone metabolism. Serum levels of BAP and osteocalcin were significantly higher in patients with severe coronary artery calcification in comparison with those without calcification. Serum level of cathepsin K was significantly lower in patients with a high risk of fatal coronary events compared to those with a low risk. Conclusions: Increase in BTMs in male patients with CAD indicates a high rate of bone loss that may confirm the common mechanisms of bone resorption and vascular calcification. |
| format | Article |
| id | doaj-art-44ec42d8fc3449b5a88e7db9e933edf1 |
| institution | Kabale University |
| issn | 2500-0764 2542-0941 |
| language | Russian |
| publishDate | 2016-03-01 |
| publisher | Kemerovo State Medical University |
| record_format | Article |
| series | Фундаментальная и клиническая медицина |
| spelling | doaj-art-44ec42d8fc3449b5a88e7db9e933edf12025-08-20T03:42:38ZrusKemerovo State Medical UniversityФундаментальная и клиническая медицина2500-07642542-09412016-03-011126325BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASEAnna V. Voronkina0Tatiana A. Raskina1Elena B. Malyuta2Marina V. Letaeva3Oksana N. Hryachkova4Alexandr N. Kokov5Olga L. Barbarash6City Clinical Hospital № 3, KemerovoKemerovo State Medical UniversityCity Clinical Hospital № 3, KemerovoKemerovo State Medical UniversityResearch Institute for Complex Issues of Cardiovascular Diseases, KemerovoResearch Institute for Complex Issues of Cardiovascular Diseases, KemerovoResearch Institute for Complex Issues of Cardiovascular Diseases, KemerovoAim: Тo study the bone turnover markers (BTMs) in male patients with coronary artery disease (CAD). Materials and Methods: We recruited 102 male patients with CAD (mean age 60.8±6.9 years) and performed coronary angiography along with a multislice computed tomography following the measurement of BTMs (osteocalcin, bone alkaline phosphatase (BAP), and cathepsin K). Coronary artery calcification was evaluated by Agatston score. Results: We found a significant increase in serum levels of BAP and cathepsin K in patients with CAD compared to the healthy controls, indicating a high rate of bone metabolism. Serum levels of BAP and osteocalcin were significantly higher in patients with severe coronary artery calcification in comparison with those without calcification. Serum level of cathepsin K was significantly lower in patients with a high risk of fatal coronary events compared to those with a low risk. Conclusions: Increase in BTMs in male patients with CAD indicates a high rate of bone loss that may confirm the common mechanisms of bone resorption and vascular calcification.https://fcm.kemsmu.ru/jour/article/view/6ишемическая болезнь сердцаостеопорозкальцинозкатепсин ккостная щелочная фосфатазаостеокальцинcoronary heart diseaseosteoporosiscalcificationcatepsin kbone akaline phosphataseosteocalcin |
| spellingShingle | Anna V. Voronkina Tatiana A. Raskina Elena B. Malyuta Marina V. Letaeva Oksana N. Hryachkova Alexandr N. Kokov Olga L. Barbarash BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE Фундаментальная и клиническая медицина ишемическая болезнь сердца остеопороз кальциноз катепсин к костная щелочная фосфатаза остеокальцин coronary heart disease osteoporosis calcification catepsin k bone akaline phosphatase osteocalcin |
| title | BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE |
| title_full | BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE |
| title_fullStr | BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE |
| title_full_unstemmed | BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE |
| title_short | BONE TURNOVER MARKERS IN MALE PATIENTS WITH CORONARY ARTERY DISEASE |
| title_sort | bone turnover markers in male patients with coronary artery disease |
| topic | ишемическая болезнь сердца остеопороз кальциноз катепсин к костная щелочная фосфатаза остеокальцин coronary heart disease osteoporosis calcification catepsin k bone akaline phosphatase osteocalcin |
| url | https://fcm.kemsmu.ru/jour/article/view/6 |
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