Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy
Context Diabetic peripheral neuropathy (DPN) results in an enormous burden and reduces the quality of life for patients. Considering there is no specific drug for the management of DPN, traditional Chinese medicine (TCM) has increasingly drawn attention of clinicians and researchers around the world...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Pharmaceutical Biology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13880209.2024.2369301 |
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| _version_ | 1850168863685083136 |
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| author | Yuna Zhang Xianglong Wu Wenhui Yao Yadong Ni Xuansheng Ding |
| author_facet | Yuna Zhang Xianglong Wu Wenhui Yao Yadong Ni Xuansheng Ding |
| author_sort | Yuna Zhang |
| collection | DOAJ |
| description | Context Diabetic peripheral neuropathy (DPN) results in an enormous burden and reduces the quality of life for patients. Considering there is no specific drug for the management of DPN, traditional Chinese medicine (TCM) has increasingly drawn attention of clinicians and researchers around the world due to its characteristics of multiple targets, active components, and exemplary safety.Objective To summarize the current status of TCM in the treatment of DPN and provide directions for novel drug development, the clinical effects and potential mechanisms of TCM used in treating DPN were comprehensively reviewed.Methods Existing evidence on TCM interventions for DPN was screened from databases such as PubMed, the Cochrane Neuromuscular Disease Group Specialized Register (CENTRAL), and the Chinese National Knowledge Infrastructure Database (CNKI). The focus was on summarizing and analyzing representative preclinical and clinical TCM studies published before 2023.Results This review identified the ameliorative effects of about 22 single herbal extracts, more than 30 herbal compound prescriptions, and four Chinese patent medicines on DPN in preclinical and clinical research. The latest advances in the mechanism highlight that TCM exerts its beneficial effects on DPN by inhibiting inflammation, oxidative stress and apoptosis, endoplasmic reticulum stress and improving mitochondrial function.Conclusions TCM has shown the power latent capacity in treating DPN. It is proposed that more large-scale and multi-center randomized controlled clinical trials and fundamental experiments should be conducted to further verify these findings. |
| format | Article |
| id | doaj-art-44ea844e44dc4974b93de729ea064351 |
| institution | OA Journals |
| issn | 1388-0209 1744-5116 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Pharmaceutical Biology |
| spelling | doaj-art-44ea844e44dc4974b93de729ea0643512025-08-20T02:20:52ZengTaylor & Francis GroupPharmaceutical Biology1388-02091744-51162024-12-0162154456110.1080/13880209.2024.2369301Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathyYuna Zhang0Xianglong Wu1Wenhui Yao2Yadong Ni3Xuansheng Ding4School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, ChinaContext Diabetic peripheral neuropathy (DPN) results in an enormous burden and reduces the quality of life for patients. Considering there is no specific drug for the management of DPN, traditional Chinese medicine (TCM) has increasingly drawn attention of clinicians and researchers around the world due to its characteristics of multiple targets, active components, and exemplary safety.Objective To summarize the current status of TCM in the treatment of DPN and provide directions for novel drug development, the clinical effects and potential mechanisms of TCM used in treating DPN were comprehensively reviewed.Methods Existing evidence on TCM interventions for DPN was screened from databases such as PubMed, the Cochrane Neuromuscular Disease Group Specialized Register (CENTRAL), and the Chinese National Knowledge Infrastructure Database (CNKI). The focus was on summarizing and analyzing representative preclinical and clinical TCM studies published before 2023.Results This review identified the ameliorative effects of about 22 single herbal extracts, more than 30 herbal compound prescriptions, and four Chinese patent medicines on DPN in preclinical and clinical research. The latest advances in the mechanism highlight that TCM exerts its beneficial effects on DPN by inhibiting inflammation, oxidative stress and apoptosis, endoplasmic reticulum stress and improving mitochondrial function.Conclusions TCM has shown the power latent capacity in treating DPN. It is proposed that more large-scale and multi-center randomized controlled clinical trials and fundamental experiments should be conducted to further verify these findings.https://www.tandfonline.com/doi/10.1080/13880209.2024.2369301Diabetes mellitusperipheral nervous system diseasessingle herbsself-composed Chinese herbal compound prescriptionChinese patent medicineinflammatory reaction |
| spellingShingle | Yuna Zhang Xianglong Wu Wenhui Yao Yadong Ni Xuansheng Ding Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy Pharmaceutical Biology Diabetes mellitus peripheral nervous system diseases single herbs self-composed Chinese herbal compound prescription Chinese patent medicine inflammatory reaction |
| title | Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy |
| title_full | Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy |
| title_fullStr | Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy |
| title_full_unstemmed | Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy |
| title_short | Advances of traditional Chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy |
| title_sort | advances of traditional chinese medicine preclinical mechanisms and clinical studies on diabetic peripheral neuropathy |
| topic | Diabetes mellitus peripheral nervous system diseases single herbs self-composed Chinese herbal compound prescription Chinese patent medicine inflammatory reaction |
| url | https://www.tandfonline.com/doi/10.1080/13880209.2024.2369301 |
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