Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms
This study applied network toxicology and multimodal biological approaches integrated with machine learning to systematically identify four TCS-IS-related genes, providing a comprehensive understanding of the pathophysiological relationship between triclosan exposure and ischemic stroke (IS). A pred...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325008966 |
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| author | Fangyuan Cheng Han Gao Bo Yan Fanglian Chen Ping Lei |
| author_facet | Fangyuan Cheng Han Gao Bo Yan Fanglian Chen Ping Lei |
| author_sort | Fangyuan Cheng |
| collection | DOAJ |
| description | This study applied network toxicology and multimodal biological approaches integrated with machine learning to systematically identify four TCS-IS-related genes, providing a comprehensive understanding of the pathophysiological relationship between triclosan exposure and ischemic stroke (IS). A predictive model for TCS-associated IS risk was developed, complemented by mechanistic insights through the construction of miRNA-TF-mRNA regulatory networks and GeneMANIA functional prediction maps. SHAP analysis clarified feature contributions, confirming the model's robustness. Molecular docking analysis further validated the heightened genetic vulnerability to TCS exposure in IS pathogenesis. The research offers two key contributions: 1) A quantifiable framework for assessing environmental toxicant risks in cerebrovascular diseases, and 2) Strong evidence advocating for urgent innovation in biocompatible material and enhanced regulatory oversight of TCS use. These findings fill critical gaps in environmental neurotoxicology and establish new paradigms for predictive toxicological modeling. Synopsis: Widespread triclosan exposure exacerbates human stroke risk, urging prioritized regulation of this persistent environmental toxicant in consumer and medical products. |
| format | Article |
| id | doaj-art-44e75c92032749a780f7daab2bf031e7 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-44e75c92032749a780f7daab2bf031e72025-08-20T04:02:32ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211855110.1016/j.ecoenv.2025.118551Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanismsFangyuan Cheng0Han Gao1Bo Yan2Fanglian Chen3Ping Lei4Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China; Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, ChinaDepartment of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China; Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, ChinaDepartment of Gastroenterology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi 445000, ChinaDepartment of Neurology, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100050, China; Corresponding author.Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China; Key Laboratory of Post-Trauma Neuro-Repair and Regeneration in Central Nervous System, Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Ministry of Education, Tianjin 300052, China; Corresponding author at: Department of Geriatrics, Tianjin Medical University General Hospital, Anshan Road No. 154, Tianjin 300052, China.This study applied network toxicology and multimodal biological approaches integrated with machine learning to systematically identify four TCS-IS-related genes, providing a comprehensive understanding of the pathophysiological relationship between triclosan exposure and ischemic stroke (IS). A predictive model for TCS-associated IS risk was developed, complemented by mechanistic insights through the construction of miRNA-TF-mRNA regulatory networks and GeneMANIA functional prediction maps. SHAP analysis clarified feature contributions, confirming the model's robustness. Molecular docking analysis further validated the heightened genetic vulnerability to TCS exposure in IS pathogenesis. The research offers two key contributions: 1) A quantifiable framework for assessing environmental toxicant risks in cerebrovascular diseases, and 2) Strong evidence advocating for urgent innovation in biocompatible material and enhanced regulatory oversight of TCS use. These findings fill critical gaps in environmental neurotoxicology and establish new paradigms for predictive toxicological modeling. Synopsis: Widespread triclosan exposure exacerbates human stroke risk, urging prioritized regulation of this persistent environmental toxicant in consumer and medical products.http://www.sciencedirect.com/science/article/pii/S0147651325008966TriclosanTCSIschemic strokeMolecular dockingMachine learningSHAP |
| spellingShingle | Fangyuan Cheng Han Gao Bo Yan Fanglian Chen Ping Lei Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms Ecotoxicology and Environmental Safety Triclosan TCS Ischemic stroke Molecular docking Machine learning SHAP |
| title | Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms |
| title_full | Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms |
| title_fullStr | Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms |
| title_full_unstemmed | Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms |
| title_short | Triclosan exposure potentiates ischemic stroke risk: Multi-omics integration and molecular docking unveil neurotoxic mechanisms |
| title_sort | triclosan exposure potentiates ischemic stroke risk multi omics integration and molecular docking unveil neurotoxic mechanisms |
| topic | Triclosan TCS Ischemic stroke Molecular docking Machine learning SHAP |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325008966 |
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