Silencing FGL1 promotes prostate cancer cell apoptosis and inhibits EMT progression

Silencing FGL1 promotes prostate cancer cell apoptosis and inhibits EMT progression

Abstract Emerging evidence from recent studies demonstrates that the FGL1/LAG-3 interaction axis plays a crucial role in mediating tumor immune evasion mechanisms, particularly through the suppression of T lymphocyte effector functions. However, the role of FGL1 in prostate cancer (PCa) remains uncl...

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Bibliographic Details
Main Authors: Shuaizhi Zhu, Zengshun Kou, Chengcheng Xiao, Lu Wang, Jiaxi Zhu, Yu Zheng, Hai Zhu
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Fibrinogen-like protein 1 (FGL1)
DnaJ heat shock protein family member C12 (DNAJC12)
Prostate cancer
Apoptosis
Tumor treatment
Online Access:https://doi.org/10.1038/s41598-025-04717-7
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