Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route.
Nipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use. Evaluation of countermeasure candidates requires safety testing in humans, as well as effic...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2025-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0318912 |
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| author | Sara C Johnston Ju Qiu Sarah L W Norris Rekha Panchal Elizabeth M Punger Melissa Teague Joshua L Moore David N Dyer Ondraya M Frick Stephen C Stevens Jimmy Fiallos Harold L Mills Eugene L Blue Willie B Sifford Trevor McCarson Amanda Casselman Jonathan D Latty Kathleen E Huie Ryan Adolphi Aysegul Nalca |
| author_facet | Sara C Johnston Ju Qiu Sarah L W Norris Rekha Panchal Elizabeth M Punger Melissa Teague Joshua L Moore David N Dyer Ondraya M Frick Stephen C Stevens Jimmy Fiallos Harold L Mills Eugene L Blue Willie B Sifford Trevor McCarson Amanda Casselman Jonathan D Latty Kathleen E Huie Ryan Adolphi Aysegul Nalca |
| author_sort | Sara C Johnston |
| collection | DOAJ |
| description | Nipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use. Evaluation of countermeasure candidates requires safety testing in humans, as well as efficacy testing against lethal challenge in animal models. Herein, we describe the characterization and comparison of the intraperitoneal and intranasal Syrian golden hamster models for Nipah virus strains Malaysia and Bangladesh. Overall, the intraperitoneal route of exposure resulted in a more consistent lethal outcome, regardless of virus strain. Therefore, the IP model was subsequently used to evaluate the use of Favipiravir as a potential positive control for future studies investigating NiV countermeasures. In contrast to prior reported results regarding Favipiravir in Nipah virus-infected hamsters, Favipiravir was only fifty percent effective at preventing death following lethal challenge, regardless of Nipah virus strain. The data suggest that Favipiravir is only partially protective against Nipah virus in hamsters, and, thus, would likely not be an ideal candidate as a positive control in future efficacy studies. |
| format | Article |
| id | doaj-art-44e0f3d6d6ef4eb8a8fd98307ebc68ee |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-44e0f3d6d6ef4eb8a8fd98307ebc68ee2025-08-20T03:47:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032025-01-01205e031891210.1371/journal.pone.0318912Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route.Sara C JohnstonJu QiuSarah L W NorrisRekha PanchalElizabeth M PungerMelissa TeagueJoshua L MooreDavid N DyerOndraya M FrickStephen C StevensJimmy FiallosHarold L MillsEugene L BlueWillie B SiffordTrevor McCarsonAmanda CasselmanJonathan D LattyKathleen E HuieRyan AdolphiAysegul NalcaNipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use. Evaluation of countermeasure candidates requires safety testing in humans, as well as efficacy testing against lethal challenge in animal models. Herein, we describe the characterization and comparison of the intraperitoneal and intranasal Syrian golden hamster models for Nipah virus strains Malaysia and Bangladesh. Overall, the intraperitoneal route of exposure resulted in a more consistent lethal outcome, regardless of virus strain. Therefore, the IP model was subsequently used to evaluate the use of Favipiravir as a potential positive control for future studies investigating NiV countermeasures. In contrast to prior reported results regarding Favipiravir in Nipah virus-infected hamsters, Favipiravir was only fifty percent effective at preventing death following lethal challenge, regardless of Nipah virus strain. The data suggest that Favipiravir is only partially protective against Nipah virus in hamsters, and, thus, would likely not be an ideal candidate as a positive control in future efficacy studies.https://doi.org/10.1371/journal.pone.0318912 |
| spellingShingle | Sara C Johnston Ju Qiu Sarah L W Norris Rekha Panchal Elizabeth M Punger Melissa Teague Joshua L Moore David N Dyer Ondraya M Frick Stephen C Stevens Jimmy Fiallos Harold L Mills Eugene L Blue Willie B Sifford Trevor McCarson Amanda Casselman Jonathan D Latty Kathleen E Huie Ryan Adolphi Aysegul Nalca Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route. PLoS ONE |
| title | Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route. |
| title_full | Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route. |
| title_fullStr | Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route. |
| title_full_unstemmed | Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route. |
| title_short | Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route. |
| title_sort | dose response comparison of nipah virus strains malaysia and bangladesh in hamsters exposed by the intranasal or intraperitoneal route |
| url | https://doi.org/10.1371/journal.pone.0318912 |
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