Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial
Background: We decided to compare the effects of sertraline and escitalopram in the treatment of major depressive disorder in hemodialysis patients. Materials and Methods: In this single-blind randomized clinical trial, 100 patients with End-Stage Renal Disease (ESRD) undergoing hemodialysis with...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2024-09-01
|
| Series: | Novelty in Biomedicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/nbm/article/view/45198 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594065405771776 |
|---|---|
| author | Tahereh Sabaghian Roya Vaziri-Harami Seyed Alireza Ebadi Minoo Heidari Almasi Azadeh Ahmadi Koomleh Amir Behnam Kharazmi Ehsan Farhadi Mahdiyeh Miri Amir Ahmad Nassiri |
| author_facet | Tahereh Sabaghian Roya Vaziri-Harami Seyed Alireza Ebadi Minoo Heidari Almasi Azadeh Ahmadi Koomleh Amir Behnam Kharazmi Ehsan Farhadi Mahdiyeh Miri Amir Ahmad Nassiri |
| author_sort | Tahereh Sabaghian |
| collection | DOAJ |
| description | Background: We decided to compare the effects of sertraline and escitalopram in the treatment of major depressive disorder in hemodialysis patients.
Materials and Methods: In this single-blind randomized clinical trial, 100 patients with End-Stage Renal Disease (ESRD) undergoing hemodialysis with a Beck Depression Inventory (BDI) score greater than 15 who were not using medication for depression were included in the study. Then randomly assigned to two groups: (one receiving sertraline and one receiving escitalopram). Both groups were monitored using the Beck questionnaire at the end of the first, second, and third months. Additionally, side effects, treatment compliance, and mortality were compared between the two groups.
Results: In total, 100 patients with ESRD were included in the study (48 in the sertraline treatment group and 52 in the escitalopram treatment group). The results indicate that in both treatment groups, depression rates significantly decreased over time with medication (P<0.001). Comparing the depression scores over time revealed that the effect of sertraline and escitalopram in reducing depression was not significantly different. However, the depression score in the sertraline group was slightly lower than that in the escitalopram group, although this difference was not statistically significant. Side effects, treatment compliance, and mortality were comparable between the two groups.
Conclusion: In general, both sertraline and escitalopram significantly reduced the score of depression in patients, but sertraline in reducing the depression score was greater than that of escitalopram, although this difference was not significant. |
| format | Article |
| id | doaj-art-44dd5e2f85fe4b6fb94b4576b3af2029 |
| institution | Kabale University |
| issn | 2345-3907 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Novelty in Biomedicine |
| spelling | doaj-art-44dd5e2f85fe4b6fb94b4576b3af20292025-01-20T05:02:54ZengShahid Beheshti University of Medical SciencesNovelty in Biomedicine2345-39072024-09-0112410.22037/nbm.v12i4.4519835087Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled TrialTahereh Sabaghian0Roya Vaziri-Harami1Seyed Alireza Ebadi2Minoo Heidari Almasi3Azadeh Ahmadi Koomleh4Amir Behnam Kharazmi5Ehsan Farhadi6Mahdiyeh Miri7Amir Ahmad Nassiri81Clinical Research Development Center, Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran 2Behavioral Science Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran3Department of Internal Medicine, Imam Hossein Educational Hospital, School of Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran4Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran4Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran4Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran5Department of Neurosurgery, Saveh University of Medical Sciences, Saveh, Iran4Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran4Department of Internal Medicine, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, IranBackground: We decided to compare the effects of sertraline and escitalopram in the treatment of major depressive disorder in hemodialysis patients. Materials and Methods: In this single-blind randomized clinical trial, 100 patients with End-Stage Renal Disease (ESRD) undergoing hemodialysis with a Beck Depression Inventory (BDI) score greater than 15 who were not using medication for depression were included in the study. Then randomly assigned to two groups: (one receiving sertraline and one receiving escitalopram). Both groups were monitored using the Beck questionnaire at the end of the first, second, and third months. Additionally, side effects, treatment compliance, and mortality were compared between the two groups. Results: In total, 100 patients with ESRD were included in the study (48 in the sertraline treatment group and 52 in the escitalopram treatment group). The results indicate that in both treatment groups, depression rates significantly decreased over time with medication (P<0.001). Comparing the depression scores over time revealed that the effect of sertraline and escitalopram in reducing depression was not significantly different. However, the depression score in the sertraline group was slightly lower than that in the escitalopram group, although this difference was not statistically significant. Side effects, treatment compliance, and mortality were comparable between the two groups. Conclusion: In general, both sertraline and escitalopram significantly reduced the score of depression in patients, but sertraline in reducing the depression score was greater than that of escitalopram, although this difference was not significant.https://journals.sbmu.ac.ir/nbm/article/view/45198depressionhemodialysisescitalopramsertraline |
| spellingShingle | Tahereh Sabaghian Roya Vaziri-Harami Seyed Alireza Ebadi Minoo Heidari Almasi Azadeh Ahmadi Koomleh Amir Behnam Kharazmi Ehsan Farhadi Mahdiyeh Miri Amir Ahmad Nassiri Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial Novelty in Biomedicine depression hemodialysis escitalopram sertraline |
| title | Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial |
| title_full | Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial |
| title_fullStr | Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial |
| title_full_unstemmed | Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial |
| title_short | Comparison of the Effect of Sertraline and Escitalopram on the Treatment of Major Depressive Disorder in Hemodialysis Patients: A Randomized Controlled Trial |
| title_sort | comparison of the effect of sertraline and escitalopram on the treatment of major depressive disorder in hemodialysis patients a randomized controlled trial |
| topic | depression hemodialysis escitalopram sertraline |
| url | https://journals.sbmu.ac.ir/nbm/article/view/45198 |
| work_keys_str_mv | AT taherehsabaghian comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT royavaziriharami comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT seyedalirezaebadi comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT minooheidarialmasi comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT azadehahmadikoomleh comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT amirbehnamkharazmi comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT ehsanfarhadi comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT mahdiyehmiri comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial AT amirahmadnassiri comparisonoftheeffectofsertralineandescitalopramonthetreatmentofmajordepressivedisorderinhemodialysispatientsarandomizedcontrolledtrial |