Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation
Conclusion: This study initially revealed the molecular mechanism of SHK in DW by multitarget and multipathway. The PI3K–AKT signaling pathway, MAPK signaling pathway, and AGE-RAGE signaling pathways may be the main pathways of SHK in treating DW.
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-01-01
|
| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/4656485 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849732616444444672 |
|---|---|
| author | Meng Tian Junchao Wu Qian Du Jiale Han Meng Yang Xiang Li Mingzhu Li Xiaofeng Ding Yeqiang Song |
| author_facet | Meng Tian Junchao Wu Qian Du Jiale Han Meng Yang Xiang Li Mingzhu Li Xiaofeng Ding Yeqiang Song |
| author_sort | Meng Tian |
| collection | DOAJ |
| description | Conclusion: This study initially revealed the molecular mechanism of SHK in DW by multitarget and multipathway. The PI3K–AKT signaling pathway, MAPK signaling pathway, and AGE-RAGE signaling pathways may be the main pathways of SHK in treating DW. |
| format | Article |
| id | doaj-art-44d689f6af1f4c92b0dc7b79aae7cee1 |
| institution | DOAJ |
| issn | 2314-6753 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-44d689f6af1f4c92b0dc7b79aae7cee12025-08-20T03:08:18ZengWileyJournal of Diabetes Research2314-67532025-01-01202510.1155/jdr/4656485Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro InvestigationMeng Tian0Junchao Wu1Qian Du2Jiale Han3Meng Yang4Xiang Li5Mingzhu Li6Xiaofeng Ding7Yeqiang Song8First College of Clinical MedicalShanghai Skin Disease HospitalShanghai Skin Disease HospitalStomatology Hospital Affiliated to Tongji UniversityDepartment of Cosmetic DermatologyDepartment of Emergency MedicineFirst College of Clinical MedicalShanghai Skin Disease HospitalFirst College of Clinical MedicalConclusion: This study initially revealed the molecular mechanism of SHK in DW by multitarget and multipathway. The PI3K–AKT signaling pathway, MAPK signaling pathway, and AGE-RAGE signaling pathways may be the main pathways of SHK in treating DW.http://dx.doi.org/10.1155/jdr/4656485 |
| spellingShingle | Meng Tian Junchao Wu Qian Du Jiale Han Meng Yang Xiang Li Mingzhu Li Xiaofeng Ding Yeqiang Song Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation Journal of Diabetes Research |
| title | Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation |
| title_full | Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation |
| title_fullStr | Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation |
| title_full_unstemmed | Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation |
| title_short | Revealing the Mechanisms of Shikonin Against Diabetic Wounds: A Combined Network Pharmacology and In Vitro Investigation |
| title_sort | revealing the mechanisms of shikonin against diabetic wounds a combined network pharmacology and in vitro investigation |
| url | http://dx.doi.org/10.1155/jdr/4656485 |
| work_keys_str_mv | AT mengtian revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT junchaowu revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT qiandu revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT jialehan revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT mengyang revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT xiangli revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT mingzhuli revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT xiaofengding revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation AT yeqiangsong revealingthemechanismsofshikoninagainstdiabeticwoundsacombinednetworkpharmacologyandinvitroinvestigation |