Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection
Heart transplantation is an effective treatment for patients with end-stage heart failure, but faces challenges such as organ shortage and rejection. Mesenchymal stem cells (MSCs) hold promise as a potential therapy for attenuating heart transplant rejection due to their immunomodulatory activity. H...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Office of Journal of Guangxi Medical University
2024-11-01
|
| Series: | Guangxi Yike Daxue xuebao |
| Subjects: | |
| Online Access: | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.005 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850276223783010304 |
|---|---|
| author | LIU Dezhao ZENG Zhiyu |
| author_facet | LIU Dezhao ZENG Zhiyu |
| author_sort | LIU Dezhao |
| collection | DOAJ |
| description | Heart transplantation is an effective treatment for patients with end-stage heart failure, but faces challenges such as organ shortage and rejection. Mesenchymal stem cells (MSCs) hold promise as a potential therapy for attenuating heart transplant rejection due to their immunomodulatory activity. However, their clinical application is limited by issues such as the low MSC survival rate and insufficient homing efficiency after the transplantation. Exosomes (Exos) are important carriers for intercellular information delivery, with the advantages of low immunogenicity and high stability. MSC-exos can effectively deliver immunomodulatory molecules, promote tissue repair and immune tolerance, and thus attenuate heart transplant rejection. Studies have shown that MSC-exos can effectively overcome the deficiencies of MSCs cell therapy and are expected to be a new way to better attenuate heart transplant rejection. Therefore, this article reviews the current research status of heart transplantation and the research progress of MSC-exos in the field of heart transplantation in recent years, with the aim of providing new ideas to better improve the survival rate of heart transplant patients. |
| format | Article |
| id | doaj-art-44d4418983704eeab33181378740c84f |
| institution | OA Journals |
| issn | 1005-930X |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Office of Journal of Guangxi Medical University |
| record_format | Article |
| series | Guangxi Yike Daxue xuebao |
| spelling | doaj-art-44d4418983704eeab33181378740c84f2025-08-20T01:50:22ZzhoEditorial Office of Journal of Guangxi Medical UniversityGuangxi Yike Daxue xuebao1005-930X2024-11-0141111477148210.16190/j.cnki.45-1211/r.2024.11.005gxykdxxb-41-11-1477Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejectionLIU Dezhao0ZENG Zhiyu1Department of Cardiovascular Medicine, the First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Nanning 530021, ChinaDepartment of Cardiovascular Medicine, the First Affiliated Hospital of Guangxi Medical University, Guangxi Key Laboratory of Precision Medicine for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Nanning 530021, ChinaHeart transplantation is an effective treatment for patients with end-stage heart failure, but faces challenges such as organ shortage and rejection. Mesenchymal stem cells (MSCs) hold promise as a potential therapy for attenuating heart transplant rejection due to their immunomodulatory activity. However, their clinical application is limited by issues such as the low MSC survival rate and insufficient homing efficiency after the transplantation. Exosomes (Exos) are important carriers for intercellular information delivery, with the advantages of low immunogenicity and high stability. MSC-exos can effectively deliver immunomodulatory molecules, promote tissue repair and immune tolerance, and thus attenuate heart transplant rejection. Studies have shown that MSC-exos can effectively overcome the deficiencies of MSCs cell therapy and are expected to be a new way to better attenuate heart transplant rejection. Therefore, this article reviews the current research status of heart transplantation and the research progress of MSC-exos in the field of heart transplantation in recent years, with the aim of providing new ideas to better improve the survival rate of heart transplant patients.https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.005heart transplantationrejectionmesenchymal stem cellsexosomes |
| spellingShingle | LIU Dezhao ZENG Zhiyu Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection Guangxi Yike Daxue xuebao heart transplantation rejection mesenchymal stem cells exosomes |
| title | Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection |
| title_full | Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection |
| title_fullStr | Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection |
| title_full_unstemmed | Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection |
| title_short | Progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection |
| title_sort | progress in the study of the role of mesenchymal stem cell exosomes in heart transplant rejection |
| topic | heart transplantation rejection mesenchymal stem cells exosomes |
| url | https://journal.gxmu.edu.cn/article/doi/10.16190/j.cnki.45-1211/r.2024.11.005 |
| work_keys_str_mv | AT liudezhao progressinthestudyoftheroleofmesenchymalstemcellexosomesinhearttransplantrejection AT zengzhiyu progressinthestudyoftheroleofmesenchymalstemcellexosomesinhearttransplantrejection |