Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature review
The review article discusses the issues of anticoagulant therapy in cardiovascular patients with thrombocytopenia (TP), gives the concept of ethylenediaminetetraacetic acidand heparin-induced TP. The management of patients with heparin-induced TP is analyzed in detail, which consists in the disconti...
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| Format: | Article |
| Language: | Russian |
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«FIRMA «SILICEA» LLC
2023-09-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/5408 |
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| author | K. G. Pereverzeva S. S. Yakushin A. An. Korshikova |
| author_facet | K. G. Pereverzeva S. S. Yakushin A. An. Korshikova |
| author_sort | K. G. Pereverzeva |
| collection | DOAJ |
| description | The review article discusses the issues of anticoagulant therapy in cardiovascular patients with thrombocytopenia (TP), gives the concept of ethylenediaminetetraacetic acidand heparin-induced TP. The management of patients with heparin-induced TP is analyzed in detail, which consists in the discontinuation of unfractionated and low molecular weight heparin administration with replacement to direct thrombin inhibitors (lepirudin or argatroban), fondaparinux or direct oral anticoagulants.The authors emphasize that the anticoagulant administration to most patients with platelet count >50×109/l is possible in full prophylactic and therapeutic doses. Reducing the level of platelets to 25-50×109/l in most cases requires a reduction in the anticoagulant dose by 50%. At a platelet level of 20-25×109/l or less, anticoagulant therapy should be avoided in most patients.In addition to the scope of anticoagulant therapy, TP also determines the choice of anticoagulant as follows: in patients with acute coronary syndrome, bivalirudin or fondaparinux are recommended, while in patients with cancer and stable TP, warfarin or direct oral anticoagulants can be prescribed. In progressive TP (if heparin-induced TP is ruled out), low molecular weight heparins should be used. |
| format | Article |
| id | doaj-art-44cf7e368bc84787a5e3e47e1d61d9ee |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2023-09-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-44cf7e368bc84787a5e3e47e1d61d9ee2025-08-20T03:43:37Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202023-09-0128810.15829/1560-4071-202354083873Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature reviewK. G. Pereverzeva0S. S. Yakushin1A. An. Korshikova2I.P. Pavlov Ryazan State Medical UniversityI.P. Pavlov Ryazan State Medical UniversityI.P. Pavlov Ryazan State Medical UniversityThe review article discusses the issues of anticoagulant therapy in cardiovascular patients with thrombocytopenia (TP), gives the concept of ethylenediaminetetraacetic acidand heparin-induced TP. The management of patients with heparin-induced TP is analyzed in detail, which consists in the discontinuation of unfractionated and low molecular weight heparin administration with replacement to direct thrombin inhibitors (lepirudin or argatroban), fondaparinux or direct oral anticoagulants.The authors emphasize that the anticoagulant administration to most patients with platelet count >50×109/l is possible in full prophylactic and therapeutic doses. Reducing the level of platelets to 25-50×109/l in most cases requires a reduction in the anticoagulant dose by 50%. At a platelet level of 20-25×109/l or less, anticoagulant therapy should be avoided in most patients.In addition to the scope of anticoagulant therapy, TP also determines the choice of anticoagulant as follows: in patients with acute coronary syndrome, bivalirudin or fondaparinux are recommended, while in patients with cancer and stable TP, warfarin or direct oral anticoagulants can be prescribed. In progressive TP (if heparin-induced TP is ruled out), low molecular weight heparins should be used.https://russjcardiol.elpub.ru/jour/article/view/5408anticoagulant therapy for thrombocytopeniathrombocytopeniaanticoagulantsheparin-induced thrombocytopeniaethylenediaminetetraacetic acid-induced pseudothrombocytopenia |
| spellingShingle | K. G. Pereverzeva S. S. Yakushin A. An. Korshikova Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature review Российский кардиологический журнал anticoagulant therapy for thrombocytopenia thrombocytopenia anticoagulants heparin-induced thrombocytopenia ethylenediaminetetraacetic acid-induced pseudothrombocytopenia |
| title | Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature review |
| title_full | Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature review |
| title_fullStr | Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature review |
| title_full_unstemmed | Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature review |
| title_short | Potential of anticoagulant therapy in cardiology practice for thrombocytopenia. Literature review |
| title_sort | potential of anticoagulant therapy in cardiology practice for thrombocytopenia literature review |
| topic | anticoagulant therapy for thrombocytopenia thrombocytopenia anticoagulants heparin-induced thrombocytopenia ethylenediaminetetraacetic acid-induced pseudothrombocytopenia |
| url | https://russjcardiol.elpub.ru/jour/article/view/5408 |
| work_keys_str_mv | AT kgpereverzeva potentialofanticoagulanttherapyincardiologypracticeforthrombocytopenialiteraturereview AT ssyakushin potentialofanticoagulanttherapyincardiologypracticeforthrombocytopenialiteraturereview AT aankorshikova potentialofanticoagulanttherapyincardiologypracticeforthrombocytopenialiteraturereview |