Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways

Resveratrol attenuates hepatic oxidative stress and preserves gut mucosal integrity in high-fat diet-fed rats by modulating antioxidant and anti-inflammatory pathways

Abstract This study evaluated the protective effects of resveratrol against high-fat diet (HFD)-induced hepatic dysfunction and intestinal mucus layer depletion with a focus on antioxidant and anti-inflammatory mechanisms. HFD-fed rats were treated with resveratrol for 8 weeks, and various metabolic...

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Main Authors: Tahmina Yasmin, Sreelakshmi N. Menon, Ajay Pandey, Shahnaz Siddiqua, Syed Abdul Kuddus, Md. Mizanur Rahman, Ferdous Khan, Nazia Hoque, Md. Sohel Rana, Nusrat Subhan, Emran Habibi, Fatemeh Ramezani, Satyajit D. Sarker, Lutfun Nahar, Md. Ashraful Alam, Raquibul Hasan
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
High fat diet
Oxidative stress
Inflammation
Resveratrol
Non-alcoholic fatty liver disease
Intestinal mucosal barrier
Online Access:https://doi.org/10.1038/s41598-025-08450-z
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