Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applications
Extracellular vesicles (EVs) are cell-derived particles that facilitate intercellular communication by carrying bioactive molecules like proteins and RNA, impacting both health and disease. Herein, the EVs' significance in physiological and pathological processes is reviewed, emphasising their...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1592391/full |
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| author | Debarati Bhowmik Mohamed T. Patel Mohamed T. Patel Pola Goldberg Oppenheimer Pola Goldberg Oppenheimer Pola Goldberg Oppenheimer |
| author_facet | Debarati Bhowmik Mohamed T. Patel Mohamed T. Patel Pola Goldberg Oppenheimer Pola Goldberg Oppenheimer Pola Goldberg Oppenheimer |
| author_sort | Debarati Bhowmik |
| collection | DOAJ |
| description | Extracellular vesicles (EVs) are cell-derived particles that facilitate intercellular communication by carrying bioactive molecules like proteins and RNA, impacting both health and disease. Herein, the EVs' significance in physiological and pathological processes is reviewed, emphasising their potential as biomarkers for diseases including for instance, cancer, neurodegenerative disorders and cardiovascular conditions. The principles and applications of Raman spectroscopy (RS) - a powerful tool offering detailed molecular insights into EVs, are further examined. The non-destructive nature of this spectroscopic technique renders it invaluable for studying the molecular composition, purity and concentration of EVs. When EVs are isolated from accessible biofluids such as blood, urine or saliva, the overall process remains minimally invasive, enhancing its clinical applicability. The review highlights Raman spectroscopy’s role in identifying disease-related EVs, distinguishing subpopulations and enhancing our understanding of EVs in disease mechanisms and therapeutic applications. |
| format | Article |
| id | doaj-art-44bf9ccbb659462492cbd9f5bddca416 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-44bf9ccbb659462492cbd9f5bddca4162025-08-20T03:53:18ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-05-011310.3389/fbioe.2025.15923911592391Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applicationsDebarati Bhowmik0Mohamed T. Patel1Mohamed T. Patel2Pola Goldberg Oppenheimer3Pola Goldberg Oppenheimer4Pola Goldberg Oppenheimer5Advanced Nanomaterials Structures and Applications Laboratories, School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham, United KingdomAdvanced Nanomaterials Structures and Applications Laboratories, School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham, United KingdomHealthcare Technologies Institute, Institute of Translational Medicine, Birmingham, United KingdomAdvanced Nanomaterials Structures and Applications Laboratories, School of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Birmingham, United KingdomHealthcare Technologies Institute, Institute of Translational Medicine, Birmingham, United KingdomCavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, United KingdomExtracellular vesicles (EVs) are cell-derived particles that facilitate intercellular communication by carrying bioactive molecules like proteins and RNA, impacting both health and disease. Herein, the EVs' significance in physiological and pathological processes is reviewed, emphasising their potential as biomarkers for diseases including for instance, cancer, neurodegenerative disorders and cardiovascular conditions. The principles and applications of Raman spectroscopy (RS) - a powerful tool offering detailed molecular insights into EVs, are further examined. The non-destructive nature of this spectroscopic technique renders it invaluable for studying the molecular composition, purity and concentration of EVs. When EVs are isolated from accessible biofluids such as blood, urine or saliva, the overall process remains minimally invasive, enhancing its clinical applicability. The review highlights Raman spectroscopy’s role in identifying disease-related EVs, distinguishing subpopulations and enhancing our understanding of EVs in disease mechanisms and therapeutic applications.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1592391/fullextracellular vesiclesRaman spectroscopyRaman imagingdisease diagnosticsSERS (surface enhanced Raman scattering) |
| spellingShingle | Debarati Bhowmik Mohamed T. Patel Mohamed T. Patel Pola Goldberg Oppenheimer Pola Goldberg Oppenheimer Pola Goldberg Oppenheimer Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applications Frontiers in Bioengineering and Biotechnology extracellular vesicles Raman spectroscopy Raman imaging disease diagnostics SERS (surface enhanced Raman scattering) |
| title | Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applications |
| title_full | Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applications |
| title_fullStr | Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applications |
| title_full_unstemmed | Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applications |
| title_short | Illuminating extracellular nanovesicles through the spectroscopic lens: a mini review of cutting-edge insights and emerging applications |
| title_sort | illuminating extracellular nanovesicles through the spectroscopic lens a mini review of cutting edge insights and emerging applications |
| topic | extracellular vesicles Raman spectroscopy Raman imaging disease diagnostics SERS (surface enhanced Raman scattering) |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1592391/full |
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