Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase

Abstract Phospholipids are the most abundant component in lipid membranes and are essential for the structural and functional integrity of the cell. In eukaryotic cells, phospholipids are primarily synthesized de novo through the Kennedy pathway that involves multiple enzymatic processes. The termin...

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Main Authors: Jacquelyn R. Roberts, Yasuhiro Horibata, Frank E. Kwarcinski, Vinson Lam, Ashleigh M. Raczkowski, Akane Hubbard, Betsy White, Hiroyuki Sugimoto, Gregory G. Tall, Melanie D. Ohi, Shoji Maeda
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55673-1
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