Accelerating Biologics PBPK Modelling with Automated Model Building: A Tutorial

Accelerating Biologics PBPK Modelling with Automated Model Building: A Tutorial

Physiologically based pharmacokinetic (PBPK) modelling for biologics, such as monoclonal antibodies and therapeutic proteins, involves capturing complex processes, including target-mediated drug disposition (TMDD), FcRn-mediated recycling, and tissue-specific distribution. The Simcyp Designer Biolog...

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Bibliographic Details
Main Authors: Abdallah Derbalah, Tariq Abdulla, Mailys De Sousa Mendes, Qier Wu, Felix Stader, Masoud Jamei, Iain Gardner, Armin Sepp
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
PBPK
biologics
mAbs
oligonucleotides
automation
Simcyp Designer
Online Access:https://www.mdpi.com/1999-4923/17/5/604
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