In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model
Aim: In this study, we aimed to evaluate soft tissue generated by periosteal distraction. Background: Management of soft tissue defects represents a challenge in dentistry. Previous periosteal distraction studies documented partial fill of the distraction space with newly-generated bone and fibrous...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2021-11-01
|
| Series: | Saudi Dental Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905220307628 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850189488499720192 |
|---|---|
| author | Osama Zakaria |
| author_facet | Osama Zakaria |
| author_sort | Osama Zakaria |
| collection | DOAJ |
| description | Aim: In this study, we aimed to evaluate soft tissue generated by periosteal distraction. Background: Management of soft tissue defects represents a challenge in dentistry. Previous periosteal distraction studies documented partial fill of the distraction space with newly-generated bone and fibrous connective tissue. Material and methods: Titanium meshes were inserted in subperiosteal tunnels in the calvaria of 20 rats through coronal incision. The devices were immediately activated after insertion by elevation of one side at 1 mm/day for 3 days. Rats were then divided into two groups (n = 10). Animals were sacrificed after 2 weeks (Group 1) and after 4 weeks (Group 2). Distraction sites specimens were embedded in paraffin and analyzed histologically and histomorphometrically. Results: In both groups, new periosteum was regenerated and covered the original bone surface in the distraction site. Distraction spaces showed a predomination of hyper-vascularized connective tissue and little new bone formation near to the stable end of the device. The 4-week findings showed more organized collagen fibers with less vascularity compared to the 2-week findings. Conclusion: The periosteal distraction technique can effectively regenerate connective tissue. It may open a new modality in the guided tissue regeneration for soft tissue augmentation. |
| format | Article |
| id | doaj-art-44b1cc865ffe4ae886fc9ba68e9e9af1 |
| institution | OA Journals |
| issn | 1013-9052 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Springer |
| record_format | Article |
| series | Saudi Dental Journal |
| spelling | doaj-art-44b1cc865ffe4ae886fc9ba68e9e9af12025-08-20T02:15:37ZengSpringerSaudi Dental Journal1013-90522021-11-0133758759410.1016/j.sdentj.2020.06.001In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial modelOsama Zakaria0Department of Biomedical Dental Sciences, Oral and Maxillofacial Division, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, 31441 Dammam, Saudi ArabiaAim: In this study, we aimed to evaluate soft tissue generated by periosteal distraction. Background: Management of soft tissue defects represents a challenge in dentistry. Previous periosteal distraction studies documented partial fill of the distraction space with newly-generated bone and fibrous connective tissue. Material and methods: Titanium meshes were inserted in subperiosteal tunnels in the calvaria of 20 rats through coronal incision. The devices were immediately activated after insertion by elevation of one side at 1 mm/day for 3 days. Rats were then divided into two groups (n = 10). Animals were sacrificed after 2 weeks (Group 1) and after 4 weeks (Group 2). Distraction sites specimens were embedded in paraffin and analyzed histologically and histomorphometrically. Results: In both groups, new periosteum was regenerated and covered the original bone surface in the distraction site. Distraction spaces showed a predomination of hyper-vascularized connective tissue and little new bone formation near to the stable end of the device. The 4-week findings showed more organized collagen fibers with less vascularity compared to the 2-week findings. Conclusion: The periosteal distraction technique can effectively regenerate connective tissue. It may open a new modality in the guided tissue regeneration for soft tissue augmentation.http://www.sciencedirect.com/science/article/pii/S1013905220307628Soft tissueAugmentationRegenerationPeriosteal distraction |
| spellingShingle | Osama Zakaria In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model Saudi Dental Journal Soft tissue Augmentation Regeneration Periosteal distraction |
| title | In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model |
| title_full | In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model |
| title_fullStr | In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model |
| title_full_unstemmed | In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model |
| title_short | In situ soft tissue regeneration using periosteal distraction: A preliminary study in the rat calvarial model |
| title_sort | in situ soft tissue regeneration using periosteal distraction a preliminary study in the rat calvarial model |
| topic | Soft tissue Augmentation Regeneration Periosteal distraction |
| url | http://www.sciencedirect.com/science/article/pii/S1013905220307628 |
| work_keys_str_mv | AT osamazakaria insitusofttissueregenerationusingperiostealdistractionapreliminarystudyintheratcalvarialmodel |