Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid
Focus of this study is on the use of the hydrazone compound (3) (N-(4-bromobenzylidene)-4-(1H-indol-3-yl) butane hydrazide), which was previously prepared from the reaction of the compound p-bromobenzaldehyde with the corresponding hydrazide (2), as an intermediate compound for the synthesis of azet...
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Elsevier
2025-03-01
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| Series: | Journal of Genetic Engineering and Biotechnology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1687157X24001550 |
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| author | Azhar H. Ali Mohanad Yakdhan Saleh Qusay Abdulazahra Yaqoob Shakir M. Saied Mohammed Sami Hasan Khalid Ahmed Owaid Basma A.A. Balboul Heba.G. Abdelzaher M.A. Abdelzaher Alaa Muqbil Alsirhani |
| author_facet | Azhar H. Ali Mohanad Yakdhan Saleh Qusay Abdulazahra Yaqoob Shakir M. Saied Mohammed Sami Hasan Khalid Ahmed Owaid Basma A.A. Balboul Heba.G. Abdelzaher M.A. Abdelzaher Alaa Muqbil Alsirhani |
| author_sort | Azhar H. Ali |
| collection | DOAJ |
| description | Focus of this study is on the use of the hydrazone compound (3) (N-(4-bromobenzylidene)-4-(1H-indol-3-yl) butane hydrazide), which was previously prepared from the reaction of the compound p-bromobenzaldehyde with the corresponding hydrazide (2), as an intermediate compound for the synthesis of azetidine, thiazolidine, tetrazole, oxadiazole and phthalazine heterocyclic compounds through its reaction with some cyclic reagents and catalysts such as chloro acetyl chloride, thioglycolic acid, sodium-azid, lead dioxide and Hydrogen chloride gas. The prepared compounds were characterized using physical properties and also spectroscopic methods such as infrared spectroscopy, nuclear magnetic resonance spectra of the proton and the isotope of carbon13 as well as mass spectrometry, which accurately identified the proposed structures of the prepared compounds. The identity of the prepared compounds was determined using physical and spectroscopic properties, where infrared and 1HNMR spectroscopy of the proton as well as carbon13 were used in addition to using mass spectrometry to verify the validity of the prepared structures. Conclusions: Also, the biological antibacterial evaluation of the compounds (4–8) was conducted and it gave a good result compared to the drug (8) used as a reference for the control, The MTT test was performed on the healthy and cancerous cells of the compounds (4,5,8) and gave an excellent result for the compound (8). |
| format | Article |
| id | doaj-art-44aed1b6248c4295a9af7da954eb87fa |
| institution | OA Journals |
| issn | 1687-157X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Genetic Engineering and Biotechnology |
| spelling | doaj-art-44aed1b6248c4295a9af7da954eb87fa2025-08-20T01:58:27ZengElsevierJournal of Genetic Engineering and Biotechnology1687-157X2025-03-0123110045210.1016/j.jgeb.2024.100452Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acidAzhar H. Ali0Mohanad Yakdhan Saleh1Qusay Abdulazahra Yaqoob2Shakir M. Saied3Mohammed Sami Hasan4Khalid Ahmed Owaid5Basma A.A. Balboul6Heba.G. Abdelzaher7M.A. Abdelzaher8Alaa Muqbil Alsirhani9Taq Harb Intermediate School for Boys, Directorate of Education in Nineveh, Ministry of Education, Mosul, IraqDepartment of Chemistry, College of Education for Pure Science, University of Mosul, Ministry of Higher Education and Scientific Research, Mosul, IraqDepartment of Surgery, College of Medicine, University of Kufa, Al-Kufa Street, Najaf, IraqCollege of Pharmacy, Al Noor University, Al-Shallalat Road, Nineveh, IraqAnesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001 Babylon, IraqDepartment of Chemistry, College of Education for Pure Science, University of Mosul, Ministry of Higher Education and Scientific Research, Mosul, IraqDepartment of Chemistry, College of Sciences, Jouf University, PO Box 72341, Sakaka, Saudi ArabiaDepartment of Clinical Pharmacy, Faculty of Pharmacy, Minia University, 61519 Minia, EgyptAnesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001 Babylon, Iraq; Department of Chemistry, College of Sciences, Jouf University, PO Box 72341, Sakaka, Saudi Arabia; Department of Clinical Pharmacy, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt; Environmental Science and Industrial Development Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt; Corresponding author at: Anesthesia Techniques Department, College of Health and Medical Techniques, Al-Mustaqbal University, 51001 Babylon, Iraq. Environmental Science and Industrial Development Department, Faculty of Postgraduate Studies for Advanced Sciences, Beni-Suef University, Beni-Suef 62511, Egypt.Department of Chemistry, College of Sciences, Jouf University, PO Box 72341, Sakaka, Saudi ArabiaFocus of this study is on the use of the hydrazone compound (3) (N-(4-bromobenzylidene)-4-(1H-indol-3-yl) butane hydrazide), which was previously prepared from the reaction of the compound p-bromobenzaldehyde with the corresponding hydrazide (2), as an intermediate compound for the synthesis of azetidine, thiazolidine, tetrazole, oxadiazole and phthalazine heterocyclic compounds through its reaction with some cyclic reagents and catalysts such as chloro acetyl chloride, thioglycolic acid, sodium-azid, lead dioxide and Hydrogen chloride gas. The prepared compounds were characterized using physical properties and also spectroscopic methods such as infrared spectroscopy, nuclear magnetic resonance spectra of the proton and the isotope of carbon13 as well as mass spectrometry, which accurately identified the proposed structures of the prepared compounds. The identity of the prepared compounds was determined using physical and spectroscopic properties, where infrared and 1HNMR spectroscopy of the proton as well as carbon13 were used in addition to using mass spectrometry to verify the validity of the prepared structures. Conclusions: Also, the biological antibacterial evaluation of the compounds (4–8) was conducted and it gave a good result compared to the drug (8) used as a reference for the control, The MTT test was performed on the healthy and cancerous cells of the compounds (4,5,8) and gave an excellent result for the compound (8).http://www.sciencedirect.com/science/article/pii/S1687157X24001550TetrazoleOxoazetidineOxathiazolidinePhthalazineBiological Antibacterial EvaluationMTT and Anticancer Activate |
| spellingShingle | Azhar H. Ali Mohanad Yakdhan Saleh Qusay Abdulazahra Yaqoob Shakir M. Saied Mohammed Sami Hasan Khalid Ahmed Owaid Basma A.A. Balboul Heba.G. Abdelzaher M.A. Abdelzaher Alaa Muqbil Alsirhani Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid Journal of Genetic Engineering and Biotechnology Tetrazole Oxoazetidine Oxathiazolidine Phthalazine Biological Antibacterial Evaluation MTT and Anticancer Activate |
| title | Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid |
| title_full | Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid |
| title_fullStr | Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid |
| title_full_unstemmed | Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid |
| title_short | Comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid |
| title_sort | comprehensive evaluation of antibacterial and anticancer activities from indole butanoic acid |
| topic | Tetrazole Oxoazetidine Oxathiazolidine Phthalazine Biological Antibacterial Evaluation MTT and Anticancer Activate |
| url | http://www.sciencedirect.com/science/article/pii/S1687157X24001550 |
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