Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1
As special condition-derived microorganisms, mangrove endophytic fungi can produce abundant and active secondary metabolites. In this paper, one strain of <i>Dothiorella</i> sp. ZJQQYZ-1 was isolated from <i>Kandelia candel</i>. As a result, six compounds were obtained from &...
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2025-04-01
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| author | Zhaokun Li Junhao Zhu Ruxue Mu Chenxi Wang Yuru Sun Bingbing Qian Ning Li Yan Chen |
| author_facet | Zhaokun Li Junhao Zhu Ruxue Mu Chenxi Wang Yuru Sun Bingbing Qian Ning Li Yan Chen |
| author_sort | Zhaokun Li |
| collection | DOAJ |
| description | As special condition-derived microorganisms, mangrove endophytic fungi can produce abundant and active secondary metabolites. In this paper, one strain of <i>Dothiorella</i> sp. ZJQQYZ-1 was isolated from <i>Kandelia candel</i>. As a result, six compounds were obtained from <i>Dothiorella</i> sp. ZJQQYZ-1, including three new benzofuran derivatives dothiofurans A-C (<b>1</b>–<b>3</b>), one new sesquiterpene dothiopene A (<b>4</b>), one new steroid phomosterol C (<b>5</b>), and three known analogs phomosterol B (<b>6</b>), phomosterol A (<b>7</b>), and pergillin (<b>8</b>). Their structures were characterized by extensive spectroscopic analysis, electronic circular dichroism (ECD), and <sup>13</sup>C NMR calculations. The bioactive assay showed that <b>7</b> exhibited significant anti-inflammatory activity with an IC<sub>50</sub> value of 4.6 μM. Furthermore, <b>7</b> effectivity suppressed the protein expression of inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW264.7 cells. |
| format | Article |
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| institution | DOAJ |
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| language | English |
| publishDate | 2025-04-01 |
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| spelling | doaj-art-44adad64c73a4e8bbafbd65d7e46b9852025-08-20T03:13:55ZengMDPI AGMicroorganisms2076-26072025-04-0113489010.3390/microorganisms13040890Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1Zhaokun Li0Junhao Zhu1Ruxue Mu2Chenxi Wang3Yuru Sun4Bingbing Qian5Ning Li6Yan Chen7School of Pharmacy, Anhui Medical University, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaSchool of Pharmacy, Anhui Medical University, Hefei 230032, ChinaAs special condition-derived microorganisms, mangrove endophytic fungi can produce abundant and active secondary metabolites. In this paper, one strain of <i>Dothiorella</i> sp. ZJQQYZ-1 was isolated from <i>Kandelia candel</i>. As a result, six compounds were obtained from <i>Dothiorella</i> sp. ZJQQYZ-1, including three new benzofuran derivatives dothiofurans A-C (<b>1</b>–<b>3</b>), one new sesquiterpene dothiopene A (<b>4</b>), one new steroid phomosterol C (<b>5</b>), and three known analogs phomosterol B (<b>6</b>), phomosterol A (<b>7</b>), and pergillin (<b>8</b>). Their structures were characterized by extensive spectroscopic analysis, electronic circular dichroism (ECD), and <sup>13</sup>C NMR calculations. The bioactive assay showed that <b>7</b> exhibited significant anti-inflammatory activity with an IC<sub>50</sub> value of 4.6 μM. Furthermore, <b>7</b> effectivity suppressed the protein expression of inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW264.7 cells.https://www.mdpi.com/2076-2607/13/4/890mangrove endophytic fungus<i>Dothiorella</i> sp.anti-inflammatory |
| spellingShingle | Zhaokun Li Junhao Zhu Ruxue Mu Chenxi Wang Yuru Sun Bingbing Qian Ning Li Yan Chen Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1 Microorganisms mangrove endophytic fungus <i>Dothiorella</i> sp. anti-inflammatory |
| title | Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1 |
| title_full | Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1 |
| title_fullStr | Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1 |
| title_full_unstemmed | Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1 |
| title_short | Metabolites with Anti-Inflammatory Activities Isolated from the Mangrove Endophytic Fungus <i>Dothiorella</i> sp. ZJQQYZ-1 |
| title_sort | metabolites with anti inflammatory activities isolated from the mangrove endophytic fungus i dothiorella i sp zjqqyz 1 |
| topic | mangrove endophytic fungus <i>Dothiorella</i> sp. anti-inflammatory |
| url | https://www.mdpi.com/2076-2607/13/4/890 |
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