Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles
Localization optoacoustic tomography (LOT) has recently emerged as an adept imaging approach for super-resolution functional microangiography at depths out of reach for conventional optical microscopy methods. LOT enables simultaneous measurements of microvascular morphology, oxygen saturation, and...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004259 |
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| author | Daniil Nozdriukhin Eva Remlova Lin Tang Shuxin Lyu Gabriella Egri Ana Torres Anxo Vidal Lars Dähne Daniel Razansky Xosé Luís Deán-Ben |
| author_facet | Daniil Nozdriukhin Eva Remlova Lin Tang Shuxin Lyu Gabriella Egri Ana Torres Anxo Vidal Lars Dähne Daniel Razansky Xosé Luís Deán-Ben |
| author_sort | Daniil Nozdriukhin |
| collection | DOAJ |
| description | Localization optoacoustic tomography (LOT) has recently emerged as an adept imaging approach for super-resolution functional microangiography at depths out of reach for conventional optical microscopy methods. LOT enables simultaneous measurements of microvascular morphology, oxygen saturation, and blood flow velocity via rapid tracking of highly-absorbing microparticulate agents. These distinctive multiparametric imaging capabilities present a remarkable clinical diagnostic potential for a wide spectrum of conditions associated with microcirculatory alterations. However, wider adoption of LOT is impeded by the lack of contrast materials verified for safe intravenous administration in humans. In this work, we developed a new formulation of polyvinyl alcohol (PVA) microbubbles coated in a layer-by-layer fashion with a sufficiently large amount of indocyanine green (ICG) molecules to enable per-particle detection amid the strong background light absorption of blood. LOT imaging of the murine brain could be achieved with no acute toxicity effects observed. Considering that both microbubbles and ICG are routinely administered in clinical ultrasound and fluorescence angiography procedures, it is anticipated that ICG-coated microbubbles will facilitate the clinical translation of LOT. |
| format | Article |
| id | doaj-art-44ad97c145dd4e11a082fd2f035f84df |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-44ad97c145dd4e11a082fd2f035f84df2025-08-20T03:13:03ZengElsevierMaterials Today Bio2590-00642025-06-013210186510.1016/j.mtbio.2025.101865Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubblesDaniil Nozdriukhin0Eva Remlova1Lin Tang2Shuxin Lyu3Gabriella Egri4Ana Torres5Anxo Vidal6Lars Dähne7Daniel Razansky8Xosé Luís Deán-Ben9Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, Switzerland; Departement of Information Technology and Electrical Engineering, ETH Zürich and Max Planck ETH Center for Learning Systems, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, Switzerland; Institute of Medical Technology, Shanxi Medical University, Taiyuan, ChinaSurflay Nanotec GmbH, Berlin, GermanyExperimental Biomedicine Centre (CEBEGA), University of Santiago de Compostela, SpainCenter for Research in Molecular Medicine and Chronic Diseases (CiMUS), Health Research Institute of Santiago de Compostela (IDIS), University of Santiago de Compostela, Santiago de Compostela, SpainSurflay Nanotec GmbH, Berlin, GermanyInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, SwitzerlandInstitute for Biomedical Engineering and Institute of Pharmacology and Toxicology, Faculty of Medicine, University of Zürich, Switzerland; Institute for Biomedical Engineering, Department of Information Technology and Electrical Engineering, ETH Zürich, SwitzerlandLocalization optoacoustic tomography (LOT) has recently emerged as an adept imaging approach for super-resolution functional microangiography at depths out of reach for conventional optical microscopy methods. LOT enables simultaneous measurements of microvascular morphology, oxygen saturation, and blood flow velocity via rapid tracking of highly-absorbing microparticulate agents. These distinctive multiparametric imaging capabilities present a remarkable clinical diagnostic potential for a wide spectrum of conditions associated with microcirculatory alterations. However, wider adoption of LOT is impeded by the lack of contrast materials verified for safe intravenous administration in humans. In this work, we developed a new formulation of polyvinyl alcohol (PVA) microbubbles coated in a layer-by-layer fashion with a sufficiently large amount of indocyanine green (ICG) molecules to enable per-particle detection amid the strong background light absorption of blood. LOT imaging of the murine brain could be achieved with no acute toxicity effects observed. Considering that both microbubbles and ICG are routinely administered in clinical ultrasound and fluorescence angiography procedures, it is anticipated that ICG-coated microbubbles will facilitate the clinical translation of LOT.http://www.sciencedirect.com/science/article/pii/S2590006425004259 |
| spellingShingle | Daniil Nozdriukhin Eva Remlova Lin Tang Shuxin Lyu Gabriella Egri Ana Torres Anxo Vidal Lars Dähne Daniel Razansky Xosé Luís Deán-Ben Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles Materials Today Bio |
| title | Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles |
| title_full | Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles |
| title_fullStr | Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles |
| title_full_unstemmed | Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles |
| title_short | Multiparametric super-resolution optoacoustic imaging with ICG-tagged microbubbles |
| title_sort | multiparametric super resolution optoacoustic imaging with icg tagged microbubbles |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004259 |
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