Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma
Background. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk,...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/7137691 |
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| author | Bryan Squires Steven D. Daveluy Michael C. Joiner Newton Hurst Michael Bishop Steven R. Miller |
| author_facet | Bryan Squires Steven D. Daveluy Michael C. Joiner Newton Hurst Michael Bishop Steven R. Miller |
| author_sort | Bryan Squires |
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| description | Background. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk, elbows, and knees. It is typically associated with upper aerodigestive tract malignancies in males. Rare cases associated with gynecological cancers have been reported, including uterine adenocarcinoma, as well as ovarian and vulvar squamous cell carcinomas. Cutaneous manifestations often precede cancer diagnosis. In most reported cases, skin changes resolve when the underlying malignancy is adequately treated. Main Observations. We present the case of a 56-year-old female diagnosed with acrokeratosis paraneoplastica following the discovery of FIGO stage IIB cervical squamous cell carcinoma (SCC). Scaling, hyperpigmentation, xerosis, and fissuring were noted on the patient’s hands, feet, legs, arms, and lower back. Pitting was noted on her fingernails. Her cervical cancer was successfully treated with chemoradiotherapy, after which her cutaneous lesions persisted for two months before resolving. Conclusions. The presentation of acrokeratosis paraneoplastica in this context is atypical. Reports of associations with gynecological cancers, as in our patient’s case, are exceedingly rare. |
| format | Article |
| id | doaj-art-44ad1445cd674f2cbe332670ec5de2dd |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-44ad1445cd674f2cbe332670ec5de2dd2025-08-20T03:36:42ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712016-01-01201610.1155/2016/71376917137691Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell CarcinomaBryan Squires0Steven D. Daveluy1Michael C. Joiner2Newton Hurst3Michael Bishop4Steven R. Miller5Karmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USAKarmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USAKarmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USAKarmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USAKarmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USAKarmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USABackground. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk, elbows, and knees. It is typically associated with upper aerodigestive tract malignancies in males. Rare cases associated with gynecological cancers have been reported, including uterine adenocarcinoma, as well as ovarian and vulvar squamous cell carcinomas. Cutaneous manifestations often precede cancer diagnosis. In most reported cases, skin changes resolve when the underlying malignancy is adequately treated. Main Observations. We present the case of a 56-year-old female diagnosed with acrokeratosis paraneoplastica following the discovery of FIGO stage IIB cervical squamous cell carcinoma (SCC). Scaling, hyperpigmentation, xerosis, and fissuring were noted on the patient’s hands, feet, legs, arms, and lower back. Pitting was noted on her fingernails. Her cervical cancer was successfully treated with chemoradiotherapy, after which her cutaneous lesions persisted for two months before resolving. Conclusions. The presentation of acrokeratosis paraneoplastica in this context is atypical. Reports of associations with gynecological cancers, as in our patient’s case, are exceedingly rare.http://dx.doi.org/10.1155/2016/7137691 |
| spellingShingle | Bryan Squires Steven D. Daveluy Michael C. Joiner Newton Hurst Michael Bishop Steven R. Miller Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma Case Reports in Dermatological Medicine |
| title | Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma |
| title_full | Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma |
| title_fullStr | Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma |
| title_full_unstemmed | Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma |
| title_short | Acrokeratosis Paraneoplastica Associated with Cervical Squamous Cell Carcinoma |
| title_sort | acrokeratosis paraneoplastica associated with cervical squamous cell carcinoma |
| url | http://dx.doi.org/10.1155/2016/7137691 |
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