ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine
Nanomedicine results from nanotechnology where molecular scale minute precise nanomotors can be used to treat disease conditions. Many such biological nanomotors are found and operate in living systems which could be used for therapeutic purposes. The question is how to build nanomachines that are c...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/567398 |
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| author | Zulfiqar Ahmad James L. Cox |
| author_facet | Zulfiqar Ahmad James L. Cox |
| author_sort | Zulfiqar Ahmad |
| collection | DOAJ |
| description | Nanomedicine results from nanotechnology where molecular scale minute precise nanomotors can be used to treat disease conditions. Many such biological nanomotors are found and operate in living systems which could be used for therapeutic purposes. The question is how to build nanomachines that are compatible with living systems and can safely operate inside the body? Here we propose that it is of paramount importance to have a workable base model for the development of nanomotors in nanomedicine usage. The base model must placate not only the basic requirements of size, number, and speed but also must have the provisions of molecular modulations. Universal occurrence and catalytic site molecular modulation capabilities are of vital importance for being a perfect base model. In this review we will provide a detailed discussion on ATP synthase as one of the most suitable base models in the development of nanomotors. We will also describe how the capabilities of molecular modulation can improve catalytic and motor function of the enzyme to generate a catalytically improved and controllable ATP synthase which in turn will help in building a superior nanomotor. For comparison, several other biological nanomotors will be described as well as their applications for nanotechnology. |
| format | Article |
| id | doaj-art-44a99ffa8ba0486e9852223614284a91 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-44a99ffa8ba0486e9852223614284a912025-02-03T05:54:02ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/567398567398ATP Synthase: The Right Size Base Model for Nanomotors in NanomedicineZulfiqar Ahmad0James L. Cox1Department of Biochemistry, Kirksville College of Osteopathic Medicine, A. T. Still University of Health Sciences, Kirksville, MO 63501, USADepartment of Biochemistry, Kirksville College of Osteopathic Medicine, A. T. Still University of Health Sciences, Kirksville, MO 63501, USANanomedicine results from nanotechnology where molecular scale minute precise nanomotors can be used to treat disease conditions. Many such biological nanomotors are found and operate in living systems which could be used for therapeutic purposes. The question is how to build nanomachines that are compatible with living systems and can safely operate inside the body? Here we propose that it is of paramount importance to have a workable base model for the development of nanomotors in nanomedicine usage. The base model must placate not only the basic requirements of size, number, and speed but also must have the provisions of molecular modulations. Universal occurrence and catalytic site molecular modulation capabilities are of vital importance for being a perfect base model. In this review we will provide a detailed discussion on ATP synthase as one of the most suitable base models in the development of nanomotors. We will also describe how the capabilities of molecular modulation can improve catalytic and motor function of the enzyme to generate a catalytically improved and controllable ATP synthase which in turn will help in building a superior nanomotor. For comparison, several other biological nanomotors will be described as well as their applications for nanotechnology.http://dx.doi.org/10.1155/2014/567398 |
| spellingShingle | Zulfiqar Ahmad James L. Cox ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine The Scientific World Journal |
| title | ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine |
| title_full | ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine |
| title_fullStr | ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine |
| title_full_unstemmed | ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine |
| title_short | ATP Synthase: The Right Size Base Model for Nanomotors in Nanomedicine |
| title_sort | atp synthase the right size base model for nanomotors in nanomedicine |
| url | http://dx.doi.org/10.1155/2014/567398 |
| work_keys_str_mv | AT zulfiqarahmad atpsynthasetherightsizebasemodelfornanomotorsinnanomedicine AT jameslcox atpsynthasetherightsizebasemodelfornanomotorsinnanomedicine |