Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones
The pace of life in the XXI century often leads to mental and physical fatigue, which can be neutralized by drugs, namely actoprotectors. Aim. To find compounds able to increase physical endurance among 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones, which are promising in this regard. Methods an...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Zaporizhzhia State Medical and Pharmaceutical University
2016-01-01
|
| Series: | Zaporožskij Medicinskij Žurnal |
| Subjects: | |
| Online Access: | http://zmj.zsmu.edu.ua/article/view/64023/60682 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850110634628218880 |
|---|---|
| author | O. M. Antypenko S. I. Kovalenko S. D. Trzhetsinsky |
| author_facet | O. M. Antypenko S. I. Kovalenko S. D. Trzhetsinsky |
| author_sort | O. M. Antypenko |
| collection | DOAJ |
| description | The pace of life in the XXI century often leads to mental and physical fatigue, which can be neutralized by drugs, namely actoprotectors.
Aim. To find compounds able to increase physical endurance among 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones, which are promising in this regard.
Methods and results. Actoprotective activity was tested on Wistar white rats by swimming test with the extra weight. It was found, that compounds, intragastrically administrated in 50 mg/kg, increased the duration of swimming in conditions of normothermia and hypothermia.
Conclusion. Rats’ swimming duration compared with control has increased for compounds 1, 4 and 7 to 55.50%, 42.36% and 22.92% against 22.20% of «Mildronate». The leading compound was revealed, namely, 6-methyltetrazolo[1,5-c]quinazolin-5(6H)-one, which exceeded the activity of reference drug in the normothermia and hypothermia. And it has been established, that sulfur in the 5th position of tetrazolo[1,5-c]quinazoline is a key element in exhibiting the actoprotective activity. |
| format | Article |
| id | doaj-art-44a6e02e41f34c9e8ec165388dbd608e |
| institution | OA Journals |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-44a6e02e41f34c9e8ec165388dbd608e2025-08-20T02:37:48ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102016-01-0118184http://dx.doi.org/10.14739/2310-1210.2016.1.64023Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-onesO. M. Antypenko S. I. KovalenkoS. D. TrzhetsinskyThe pace of life in the XXI century often leads to mental and physical fatigue, which can be neutralized by drugs, namely actoprotectors. Aim. To find compounds able to increase physical endurance among 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones, which are promising in this regard. Methods and results. Actoprotective activity was tested on Wistar white rats by swimming test with the extra weight. It was found, that compounds, intragastrically administrated in 50 mg/kg, increased the duration of swimming in conditions of normothermia and hypothermia. Conclusion. Rats’ swimming duration compared with control has increased for compounds 1, 4 and 7 to 55.50%, 42.36% and 22.92% against 22.20% of «Mildronate». The leading compound was revealed, namely, 6-methyltetrazolo[1,5-c]quinazolin-5(6H)-one, which exceeded the activity of reference drug in the normothermia and hypothermia. And it has been established, that sulfur in the 5th position of tetrazolo[1,5-c]quinazoline is a key element in exhibiting the actoprotective activity.http://zmj.zsmu.edu.ua/article/view/64023/606826-N-R-Tetrazolo[15-c]quinazolin-5(6H)-onesNormothermiaHypothermia |
| spellingShingle | O. M. Antypenko S. I. Kovalenko S. D. Trzhetsinsky Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones Zaporožskij Medicinskij Žurnal 6-N-R-Tetrazolo[1 5-c]quinazolin-5(6H)-ones Normothermia Hypothermia |
| title | Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones |
| title_full | Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones |
| title_fullStr | Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones |
| title_full_unstemmed | Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones |
| title_short | Investigation of actoprotective activity in a range of 6-N-R-tetrazolo[1,5-c]quinazolin-5(6H)-ones |
| title_sort | investigation of actoprotective activity in a range of 6 n r tetrazolo 1 5 c quinazolin 5 6h ones |
| topic | 6-N-R-Tetrazolo[1 5-c]quinazolin-5(6H)-ones Normothermia Hypothermia |
| url | http://zmj.zsmu.edu.ua/article/view/64023/60682 |
| work_keys_str_mv | AT omantypenko investigationofactoprotectiveactivityinarangeof6nrtetrazolo15cquinazolin56hones AT sikovalenko investigationofactoprotectiveactivityinarangeof6nrtetrazolo15cquinazolin56hones AT sdtrzhetsinsky investigationofactoprotectiveactivityinarangeof6nrtetrazolo15cquinazolin56hones |