Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence
Understanding the relative influences of age, pubertal development, and sex assigned at birth on brain development is a key priority of developmental neuroscience given the complex interplay of these factors in the onset of psychopathology. Previous research has investigated how these factors relate...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | NeuroImage |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925002411 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850277132213682176 |
|---|---|
| author | Kelly A. Duffy Andrea Wiglesworth Donovan J. Roediger Ellery Island Bryon A. Mueller Monica Luciana Bonnie Klimes-Dougan Kathryn R. Cullen Mark B. Fiecas |
| author_facet | Kelly A. Duffy Andrea Wiglesworth Donovan J. Roediger Ellery Island Bryon A. Mueller Monica Luciana Bonnie Klimes-Dougan Kathryn R. Cullen Mark B. Fiecas |
| author_sort | Kelly A. Duffy |
| collection | DOAJ |
| description | Understanding the relative influences of age, pubertal development, and sex assigned at birth on brain development is a key priority of developmental neuroscience given the complex interplay of these factors in the onset of psychopathology. Previous research has investigated how these factors relate to static (time-averaged) functional connectivity (FC), but little is known about their relationship with dynamic (time-varying) FC. The present study aimed to investigate the unique and overlapping roles of these factors on dynamic FC in children aged approximately 9 to 14 in the ABCD Study using a sample of 5122 low-motion resting-state scans (from 4136 unique participants). Time-varying correlations in the frontolimbic, default mode, and dorsal and ventral corticostriatal networks, estimated using the Dynamic Conditional Correlations (DCC) method, were used to calculate variability of within- and between-network connectivity and of graph theoretical measures of segregation and integration. We found decreased variability in global efficiency across the age range, and increased variability within the frontolimbic network driven primarily by those assigned female at birth (AFAB). AFAB youth specifically also showed increased variability in several other networks. Controlling for age, both advanced pubertal development and being AFAB were associated with decreased variability in all within- and between-network correlations and increased variability in measures of network segregation. These results potentially suggest advanced brain maturation in AFAB youth, particularly in key networks related to psychopathology, and lay the foundation for future investigations of dynamic FC. |
| format | Article |
| id | doaj-art-44a4bbc157864076b19cf832ae9d844d |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-44a4bbc157864076b19cf832ae9d844d2025-08-20T01:49:58ZengElsevierNeuroImage1095-95722025-06-0131312123810.1016/j.neuroimage.2025.121238Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescenceKelly A. Duffy0Andrea Wiglesworth1Donovan J. Roediger2Ellery Island3Bryon A. Mueller4Monica Luciana5Bonnie Klimes-Dougan6Kathryn R. Cullen7Mark B. Fiecas8Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Parkway, Minneapolis, MN 55455, USA; Corresponding author.Department of Psychology, University of Minnesota, Elliott Hall, 75 East River Parkway, Minneapolis, MN 55455, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota, F282/2A West Building, 2450 Riverside Avenue South, Minneapolis, MN 55454, USADivision of Biostatistics, University of Minnesota, 2221 University Ave SE, Suite 200, Minneapolis, MN 55414, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota, F282/2A West Building, 2450 Riverside Avenue South, Minneapolis, MN 55454, USADepartment of Psychology, University of Minnesota, Elliott Hall, 75 East River Parkway, Minneapolis, MN 55455, USADepartment of Psychology, University of Minnesota, Elliott Hall, 75 East River Parkway, Minneapolis, MN 55455, USADepartment of Psychiatry and Behavioral Sciences, University of Minnesota, F282/2A West Building, 2450 Riverside Avenue South, Minneapolis, MN 55454, USADivision of Biostatistics, University of Minnesota, 2221 University Ave SE, Suite 200, Minneapolis, MN 55414, USAUnderstanding the relative influences of age, pubertal development, and sex assigned at birth on brain development is a key priority of developmental neuroscience given the complex interplay of these factors in the onset of psychopathology. Previous research has investigated how these factors relate to static (time-averaged) functional connectivity (FC), but little is known about their relationship with dynamic (time-varying) FC. The present study aimed to investigate the unique and overlapping roles of these factors on dynamic FC in children aged approximately 9 to 14 in the ABCD Study using a sample of 5122 low-motion resting-state scans (from 4136 unique participants). Time-varying correlations in the frontolimbic, default mode, and dorsal and ventral corticostriatal networks, estimated using the Dynamic Conditional Correlations (DCC) method, were used to calculate variability of within- and between-network connectivity and of graph theoretical measures of segregation and integration. We found decreased variability in global efficiency across the age range, and increased variability within the frontolimbic network driven primarily by those assigned female at birth (AFAB). AFAB youth specifically also showed increased variability in several other networks. Controlling for age, both advanced pubertal development and being AFAB were associated with decreased variability in all within- and between-network correlations and increased variability in measures of network segregation. These results potentially suggest advanced brain maturation in AFAB youth, particularly in key networks related to psychopathology, and lay the foundation for future investigations of dynamic FC.http://www.sciencedirect.com/science/article/pii/S1053811925002411Dynamic functional connectivityABCD StudyDevelopmental neurosciencePubertySex differencesDynamic conditional correlations |
| spellingShingle | Kelly A. Duffy Andrea Wiglesworth Donovan J. Roediger Ellery Island Bryon A. Mueller Monica Luciana Bonnie Klimes-Dougan Kathryn R. Cullen Mark B. Fiecas Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence NeuroImage Dynamic functional connectivity ABCD Study Developmental neuroscience Puberty Sex differences Dynamic conditional correlations |
| title | Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence |
| title_full | Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence |
| title_fullStr | Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence |
| title_full_unstemmed | Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence |
| title_short | Characterizing the effects of age, puberty, and sex on variability in resting-state functional connectivity in late childhood and early adolescence |
| title_sort | characterizing the effects of age puberty and sex on variability in resting state functional connectivity in late childhood and early adolescence |
| topic | Dynamic functional connectivity ABCD Study Developmental neuroscience Puberty Sex differences Dynamic conditional correlations |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925002411 |
| work_keys_str_mv | AT kellyaduffy characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT andreawiglesworth characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT donovanjroediger characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT elleryisland characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT bryonamueller characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT monicaluciana characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT bonnieklimesdougan characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT kathrynrcullen characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence AT markbfiecas characterizingtheeffectsofagepubertyandsexonvariabilityinrestingstatefunctionalconnectivityinlatechildhoodandearlyadolescence |