In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass
IntroductionMorocco is renowned for its rich plant biodiversity, although many plants are underutilized. Consequently, the present study was conducted to assess the nutritional composition, bioactive constituents, antioxidant properties, and acute oral toxicity of Abies marocana's woody biomass...
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Frontiers Media S.A.
2025-01-01
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| author | Malak Zirari Marouane Aouji Wissal Baghdad Mohammed Er-rajy Hamada Imtara Feras Abujaber Otmane Elharrati Omar M. Noman Mahmoud Tarayrah Driss Hmouni Nouredine El Mejdoub |
| author_facet | Malak Zirari Marouane Aouji Wissal Baghdad Mohammed Er-rajy Hamada Imtara Feras Abujaber Otmane Elharrati Omar M. Noman Mahmoud Tarayrah Driss Hmouni Nouredine El Mejdoub |
| author_sort | Malak Zirari |
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| description | IntroductionMorocco is renowned for its rich plant biodiversity, although many plants are underutilized. Consequently, the present study was conducted to assess the nutritional composition, bioactive constituents, antioxidant properties, and acute oral toxicity of Abies marocana's woody biomass.MethodsThe nutritional value of the twigs and cones was determined using the AOAC method, while mineral components were examined through ICP-OES. To search for phytochemicals in the methanolic extracts, a number of established techniques were applied, and evaluate their antioxidant activity, while the volatile content was determined using the GC-MS method. The acute oral toxicity test was carried out following the guidelines of OECD 423.Results and discussionProximate analysis revealed a variety of components in different parts, including moisture, ash, fiber, protein, carbohydrates, and fat. Cones and twigs were found to be rich in mineral elements, as well as phenols, flavonoids, tannins, and phytosterols. Chromatographic analysis identified linoleic acid as the main component in twig extract and 2-Bornanone as the primary constituent in cone extract. The methanolic extracts of A. marocana displayed strong antioxidant properties through notable DPPH scavenging activity, with no mortality observed in rats even at doses exceeding 1,000 mg.kg−1, indicating potential for medicinal, cosmetic, or dietary uses. A molecular docking study of the five main compounds of both plants showed that they aligned and interacted with the binding sites of selected proteins, demonstrating significant antioxidant activity. |
| format | Article |
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| institution | Kabale University |
| issn | 2571-581X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Sustainable Food Systems |
| spelling | doaj-art-44a38c849bea4f3c97b36aa308dcef572025-01-24T07:13:56ZengFrontiers Media S.A.Frontiers in Sustainable Food Systems2571-581X2025-01-01810.3389/fsufs.2024.15255721525572In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomassMalak Zirari0Marouane Aouji1Wissal Baghdad2Mohammed Er-rajy3Hamada Imtara4Feras Abujaber5Otmane Elharrati6Omar M. Noman7Mahmoud Tarayrah8Driss Hmouni9Nouredine El Mejdoub10Laboratory of Organic Chemistry Catalysis and Environment, Department of Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoLaboratory of Natural Resources and Sustainable Development, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoLaboratory Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoLIMAS Laboratory, Faculty of Sciences Dhar El Mahraz, Sidi Mohamed Ben Abdellah University, Fez, MoroccoFaculty of Sciences, Arab American University, Ramallah, PalestineFaculty of Sciences, Arab American University, Ramallah, PalestineLaboratory Biology and Health, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaNational Center for Research in Human Genomics, Evry Courcouronnes, FranceLaboratory of Natural Resources and Sustainable Development, Department of Biology, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoLaboratory of Organic Chemistry Catalysis and Environment, Department of Chemistry, Faculty of Sciences, Ibn Tofail University, Kenitra, MoroccoIntroductionMorocco is renowned for its rich plant biodiversity, although many plants are underutilized. Consequently, the present study was conducted to assess the nutritional composition, bioactive constituents, antioxidant properties, and acute oral toxicity of Abies marocana's woody biomass.MethodsThe nutritional value of the twigs and cones was determined using the AOAC method, while mineral components were examined through ICP-OES. To search for phytochemicals in the methanolic extracts, a number of established techniques were applied, and evaluate their antioxidant activity, while the volatile content was determined using the GC-MS method. The acute oral toxicity test was carried out following the guidelines of OECD 423.Results and discussionProximate analysis revealed a variety of components in different parts, including moisture, ash, fiber, protein, carbohydrates, and fat. Cones and twigs were found to be rich in mineral elements, as well as phenols, flavonoids, tannins, and phytosterols. Chromatographic analysis identified linoleic acid as the main component in twig extract and 2-Bornanone as the primary constituent in cone extract. The methanolic extracts of A. marocana displayed strong antioxidant properties through notable DPPH scavenging activity, with no mortality observed in rats even at doses exceeding 1,000 mg.kg−1, indicating potential for medicinal, cosmetic, or dietary uses. A molecular docking study of the five main compounds of both plants showed that they aligned and interacted with the binding sites of selected proteins, demonstrating significant antioxidant activity.https://www.frontiersin.org/articles/10.3389/fsufs.2024.1525572/fullAbies marocananutritional valuewoody biomassantioxidant activityacute oral toxicitymolecular docking |
| spellingShingle | Malak Zirari Marouane Aouji Wissal Baghdad Mohammed Er-rajy Hamada Imtara Feras Abujaber Otmane Elharrati Omar M. Noman Mahmoud Tarayrah Driss Hmouni Nouredine El Mejdoub In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass Frontiers in Sustainable Food Systems Abies marocana nutritional value woody biomass antioxidant activity acute oral toxicity molecular docking |
| title | In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass |
| title_full | In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass |
| title_fullStr | In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass |
| title_full_unstemmed | In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass |
| title_short | In-depth study of the nutritional composition, phytochemicals, antioxidant activity, molecular docking interactions, and toxicological evaluation of Abies marocana Trab. woody biomass |
| title_sort | in depth study of the nutritional composition phytochemicals antioxidant activity molecular docking interactions and toxicological evaluation of abies marocana trab woody biomass |
| topic | Abies marocana nutritional value woody biomass antioxidant activity acute oral toxicity molecular docking |
| url | https://www.frontiersin.org/articles/10.3389/fsufs.2024.1525572/full |
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